RT Journal Article
SR Electronic
T1 Impact of alcohol intake on total mortality and mortality from major causes in Japan: a pooled analysis of six large-scale cohort studies
JF Journal of Epidemiology and Community Health
JO J Epidemiol Community Health
FD BMJ Publishing Group Ltd
SP 448
OP 456
DO 10.1136/jech.2010.121830
VO 66
IS 5
A1 Inoue, Manami
A1 Nagata, Chisato
A1 Tsuji, Ichiro
A1 Sugawara, Yumi
A1 Wakai, Kenji
A1 Tamakoshi, Akiko
A1 Matsuo, Keitaro
A1 Mizoue, Tetsuya
A1 Tanaka, Keitaro
A1 Sasazuki, Shizuka
A1 Tsugane, Shoichiro
A1 ,
YR 2012
UL http://jech.bmj.com/content/66/5/448.abstract
AB Objectives Using common alcohol consumption categories, to conduct a pooled analysis of six ongoing large-scale cohort studies in Japan in order to produce concrete estimates of the quantitative contribution of alcohol consumption to all-cause and major causes of mortality in the Japanese population.Methods Of the 309 082 subjects, there were 35 801 deaths during 3 832 285 person-years of follow-up. Using a random-effect model, we conducted a meta-analysis of the HRs of each alcohol consumption category in each study, thereby obtaining pooled estimates for the risk of total and major causes of mortality due to alcohol consumption.Results There was a J- or U-shaped association for the risk of total and major causes of mortality in men, and the risk of total and heart disease mortality in women. Compared with non-drinkers, there was a significantly lower risk for total mortality at an alcohol consumption level of <69 g/day, cancer mortality at <46 g/day, heart disease mortality at <69 g/day and cerebrovascular disease mortality at <46 g/day in men, and for total mortality at <23 g/day in women. In addition, mortality risk increased linearly with rising alcohol dose among drinkers. It was estimated that 5% of total mortality, 3% of cancer mortality, 2% of heart disease mortality and 9% of cerebrovascular disease mortality in men, but only 0–1% of these risks in women, could be prevented by reducing alcohol consumption to <46 g/day in men and <23 g/day in women.Conclusion Maintaining alcohol consumption below 46 g/day in men and 23 g/day in women appears to minimise the risks of mortality in the Japanese population.