PT - JOURNAL ARTICLE AU - Khalili, Davood AU - Hadaegh, Farzad AU - Fahimfar, Noushin AU - Shafiee, Gita AU - Sheikholeslami, Farhad AU - Ghanbarian, Arash AU - Azizi, Fereidoun TI - Does an electrocardiogram add predictive value to the rose angina questionnaire for future coronary heart disease? 10-year follow-up in a Middle East population AID - 10.1136/jech-2011-200242 DP - 2012 Dec 01 TA - Journal of Epidemiology and Community Health PG - 1104--1109 VI - 66 IP - 12 4099 - http://jech.bmj.com/content/66/12/1104.short 4100 - http://jech.bmj.com/content/66/12/1104.full SO - J Epidemiol Community Health2012 Dec 01; 66 AB - Background To evaluate the power of abnormal resting ECG versus Rose Questionnaire angina and its additive value in predicting 10-year coronary heart disease (CHD) risk in an Iranian urban population with high prevalence of CHD. Methods There were 5101 subjects ≥30 years (2900 women), free of CHD at baseline; they were categorised in to four groups according to their Rose Angina and ECG status for ischaemia as Rose−/ECG−, Rose+/ECG−, Rose−/ECG+ and Rose+/ECG+. HR of CHD was estimated using Cox regression analysis, given Rose−/ECG− as the reference. The authors used Akaike information criterion, C-index and integrated discrimination improvement indices to evaluate the prognostic value of ECG when would be added to Rose Questionnaire. Results During follow-up, 387 CHD events (169 women) were observed. Multivariate analysis showed a HR of 2.59 (95% CI 1.71 to 3.91) and 2.26 (1.48 to 3.44) for Rose+/ECG− group in men and women, respectively. These figures for Rose−/ECG+ were 1.36 (0.90 to 2.05) in men and 2.09 (1.40 to 3.12) in women. There was no any interaction between Rose Questionnaire and gender to predict incident CHD, in age-adjusted analysis. Akaike information criterion, C-index and relative integrated discrimination improvement did not show any difference between models including Rose alone and Rose plus ECG to predict CHD events especially in men. Conclusions Rose Questionnaire as a simple screening tool is equally important to predict incident CHD in both genders. Adding abnormal ECG to angina did not culminate in higher risk for future CHD events.