PT  - JOURNAL ARTICLE
AU  - J D Ferreira
AU  - A C Couto
AU  - M do Socorro Pombo-de-Oliveira
AU  - S Koifman
TI  - P2-82 Pregnancy, exposure to pesticides and infant leukaemia in Brazil
AID  - 10.1136/jech.2011.142976i.17
DP  - 2011 Aug 01
TA  - Journal of Epidemiology and Community Health
PG  - A242--A242
VI  - 65
IP  - Suppl 1
4099  - http://jech.bmj.com/content/65/Suppl_1/A242.3.short
4100  - http://jech.bmj.com/content/65/Suppl_1/A242.3.full
SO  - J Epidemiol Community Health2011 Aug 01; 65
AB  - Infant Leukaemia is a rare haematological neoplasm associated with MLL gene rearrangements. Maternal exposure during pregnancy to pesticides, hormones, dipyrone, and topoisomerase-II DNA inhibitors and birth weight were associated risk factors. This is a hospital-based multicenter case-control study, and were interviewed mothers of 252 IL cases and of 423 controls. Data were obtained regarding environmental maternal exposure during periconceptional, pregnancy and breast-feeding periods, including exposure to pesticides. Unconditional logistic regression was performed and ORs on the association between maternal pesticides exposure and IL, including their 95% CIs, were ascertained after adjustment to hormonal intake during pregnancy, mother's age, mother's level of education, birth weight and infant's skin colour. An adjusted OR, 2.39, 95% CI 1.63 to 3.51 was observed for the association between IL and maternal exposure to pesticides during pregnancy, being higher for acute myeloid leukaemia (adjusted OR 3.50, 95% CI 2.01 to 6.11). The use of pyrethroids during pregnancy revealed an OR 2.18 (95% CI 1.44 to 3.29), while the use of other pesticides showed an OR 3.61 (95% CI 1.69 to 7.73). The reported household use of pesticides revealed an adjusted OR 2.25 (95% CI 1.48 to 3.43), and agriculture exposure showed an adjusted OR 9.26, (95% CI 2.82 to 30.4). Mixed exposure to different pesticides showed an adjusted OR, 3.83 (95% CI 1.33 to 11.0) and the exposure to different chemical classes revealed an adjusted OR, 8.87 (95% CI 1.55 to 50.6). The observed results seem to support the hypothesis that mothers' household use of pesticides and other contaminants may be involved in the aetiology of infant leukaemia.