PT  - JOURNAL ARTICLE
AU  - J Hutchinson
AU  - M Lentjes
AU  - D Greenwood
AU  - V Burley
AU  - J Cade
AU  - C Cleghorn
AU  - D Threapleton
AU  - T Key
AU  - B Cairns
AU  - R Keogh
AU  - C Dahm
AU  - E Brunner
AU  - M Shipley
AU  - D Kuh
AU  - G Mishra
AU  - A Stephen
AU  - A Bhaniani
AU  - G Borgulya
AU  - K T Khaw
AU  - S Rodwell
TI  - P2-118 Vitamin C intake from diary recordings and risk of breast cancer in the UK dietary cohort consortium
AID  - 10.1136/jech.2011.142976i.53
DP  - 2011 Aug 01
TA  - Journal of Epidemiology and Community Health
PG  - A253--A253
VI  - 65
IP  - Suppl 1
4099  - http://jech.bmj.com/content/65/Suppl_1/A253.1.short
4100  - http://jech.bmj.com/content/65/Suppl_1/A253.1.full
SO  - J Epidemiol Community Health2011 Aug 01; 65
AB  - Introduction Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires. No study has assessed this relationship prospectively using food diaries which may more accurately measure intake.Methods Estimated dietary vitamin C intake was derived from 4 to 7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 851 incident breast cancer cases and 2727 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in the three largest cohorts.Results No evidence of an association was observed between breast cancer risk and dietary (OR=1.00 per 60 mg/d, 95% CI 0.91 to 1.09, Ptrend=1.0) or total vitamin C intake (OR=1.01 per 60 mg/d, 95% CI 1.00 to 1.03, Ptrend=0.1) in analyses using continuous estimates or by fifths of intake. Additionally, there was no association for post-menopausal women.Conclusions This pooled analysis of individual UK women found no evidence of associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings.