PT  - JOURNAL ARTICLE
AU  - N Srivastava
AU  - J Prakash
AU  - C G Agarwal
AU  - B Mittal
TI  - P2-477 The association of adiponectin gene polymorphisms (+45T>G and +276G>T) with adiponectin levels but not with characteristics of the insulin resistance syndrome in Northern India
AID  - 10.1136/jech.2011.142976m.5
DP  - 2011 Aug 01
TA  - Journal of Epidemiology and Community Health
PG  - A353--A353
VI  - 65
IP  - Suppl 1
4099  - http://jech.bmj.com/content/65/Suppl_1/A353.1.short
4100  - http://jech.bmj.com/content/65/Suppl_1/A353.1.full
SO  - J Epidemiol Community Health2011 Aug 01; 65
AB  - Introduction Adiponectin, the major adipocyte secretary protein, improves insulin sensitivity and possesses anti-inflammatory and anti atherosclerotic properties. In the present study, we investigated the association of adiponectin gene (APM1) +45T>G (rs2241766) and +276G>T (rs1501299) polymorphisms with serum adiponectin levels and metabolic parameters of the insulin resistance syndrome, in northern Indian population.Methods A case control study was conducted with 642 subjects (309 obese subjects (BMI≥30) and 333 non-obese (BMI<30) subjects) to examine the association of adiponectin gene (APM1) polymorphisms with serum adiponectin levels and other metabolic parameters in northern Indian population. All subjects were genotyped through PCR-RFLP. Insulin, leptin, lipid profile and glucose levels were estimated using standard protocols.Results The variant G-allele of SNP +45T>G and T-allele of SNP +276G>T were associated with significantly higher serum adiponectin levels (p=0.0001 and p=0.0001, respectively). The most frequent haplotype TG defined by both loci showed a strong association with lower serum adiponectin concentrations, higher levels of insulin, and HOMA-IR index.Conclusion We observed a strong association of the APM1 45–276 genotypes and TG (rs2241766, rs1501299) haplotypes with adiponectin levels in healthy northern Indians. The TG haplotype associated with higher levels of insulin, HOMA-IR index, and lower serum adiponectin concentrations.