TY - JOUR T1 - P2-178 The associations of dietary folate, vitamin B<sub>6</sub> and B<sub>12</sub> intakes with risk of sudden cardiac death: the Circulatory Risk in Communities Study (CIRCS) JF - Journal of Epidemiology and Community Health JO - J Epidemiol Community Health SP - A270 LP - A270 DO - 10.1136/jech.2011.142976j.13 VL - 65 IS - Suppl 1 AU - M Maruyama AU - T Ohira AU - H Imano AU - A Kitamura AU - M Kiyama AU - T Okada AU - K Maeda AU - K Yamagishi AU - H Noda AU - Y Ishikawa AU - T Shimamoto AU - H Iso Y1 - 2011/08/01 UR - http://jech.bmj.com/content/65/Suppl_1/A270.2.abstract N2 - Introduction To examine whether dietary folate, vitamin B6 and B12 intakes are associated with the risk of sudden cardiac death (SCD) among Japanese men and women.Method We conducted a nested case-control study. For each case of SCD entered between 1973 and 2001 in the CIRCS, two controls were randomly selected for each case and matched for age (±3 years), sex and community from among participants without history of SCD. The 77 cases and 154 controls aged 30–84 years were enrolled. Dietary folate, vitamin B6 and B12 intakes were assessed by 1 day 24 h dietary recall. We calculated conditional OR and 95% CI of each nutrients for risk of SCD adjusted for potential confounding factors.Result Higher intake of folate was associated with lower risk of SCD. The multivariable adjusted OR (95% CI) of highest quartile was 0.32 (95% CI 0.12 to 0.82), p for trend=0.06 compared with lowest quartile. However, vitamin B6 and B12 intakes were not associated with risk of SCD. The multivariable adjusted OR (95% CI) of highest quartile of vitamin B6 and B12 intakes were 1.25 (95% CI 0.49 to 3.21), p for trend=0.64 and 0.83 (95% CI 0.34 to 1.98), p for trend=0.86 compared with lowest quartiles, respectively.Conclusion Our findings suggest that higher dietary folate intake is associated with lower risk of SCD among Japanese men and women. ER -