RT Journal Article
SR Electronic
T1 Early life diarrhoea and later blood pressure in a developing country: the 1982 Pelotas (Brazil) birth cohort study
JF Journal of Epidemiology and Community Health
JO J Epidemiol Community Health
FD BMJ Publishing Group Ltd
SP 163
OP 165
DO 10.1136/jech.2008.077818
VO 63
IS 2
A1 G D Batty
A1 B L Horta
A1 G Davey Smith
A1 F C Barros
A1 C Victora
YR 2009
UL http://jech.bmj.com/content/63/2/163.abstract
AB Background: It has recently been hypothesised that acute dehydration in early childhood may “programme” increased blood pressure via salt retention. We examined whether there was an association between episodes of diarrhoea (a proxy for acute dehydration) and later measured blood pressure.Methods: In the 1982 Pelotas birth cohort study (Brazil), parents/carers reported hospital admissions for diarrhoea in the first 12 and 20 months of study members’ lives. Blood pressure was subsequently measured directly in adolescence (aged 15, 18, 19 years) and early adulthood (aged 23 years).Results: We found no evidence of an association between diarrhoea in the first 12 months of life and blood pressure measured at any point in adolescence or early adulthood. These findings were unchanged after adjustment for a range of covariates. Equally null results were apparent when diarrhoea admissions in the first 20 months of life, access to home sanitation and use of piped water were the exposures of interest.Conclusions: Early life proxies for dehydration and diarrhoea were unrelated to later blood pressure in this examination, the most comprehensive to date, of the potential association.