Global surveillance in chronic or acute infectious are really important
issues.Working in the area of pidemiology in one of the least developed
country, one important issue that remains for me is to strengthen the system to
collect, analyse
and report data scientifically, so that magnitude can be measured
quantitatively,rather than the subjective impressions of professionals.
Global surveillance in chronic or acute infectious are really important
issues.Working in the area of pidemiology in one of the least developed
country, one important issue that remains for me is to strengthen the system to
collect, analyse
and report data scientifically, so that magnitude can be measured
quantitatively,rather than the subjective impressions of professionals.
Do we have enough infrastructures for a surveillance system?
We are planning a 'patch up' approach for example with polio.What will
happen after five years, once the project is over in a country
where not a single laboratory is available to test the polio
virus be it from the wild or vaccine initiated? Our country's capacity to take the initiative
is decreasing. A vertical approach is prominent
and one more silent epidemic of chronic diseases
will not be tackled the way it should be, because there is no
institution to tackle such a problem. Identifying the problem is one step
but to build resources so that it can continue on its own is another. A surveillance system can not be
isolated without improving the overall health system.
Editor,
The results of this study may be interesting but when one
considers that junior ranks (e.g. privates) make up the majority of the British armed forces then I do not believe that this represents the true figures.
If these results were taken from the original contact list as supplied by the Ministry of Defence, then there are questions related to the sample group. I believe that one of the o...
Editor,
The results of this study may be interesting but when one
considers that junior ranks (e.g. privates) make up the majority of the British armed forces then I do not believe that this represents the true figures.
If these results were taken from the original contact list as supplied by the Ministry of Defence, then there are questions related to the sample group. I believe that one of the original problems with this group was the fact that many of the addresses supplied were out of date.
I wonder whether the same results would be reflected if a study were performed on the War Pension Agency records for ill gulf war veterans?
Phil Garner R.G.N., Cert Ad Ed, F.E.T.C.
VETNET
ill gulf war veteran - not in one of the lower socio-economic groups
Editor,
As a new grad, I found the idea of adding a glossary section to your journal to be insightful and encouraging. Just from an operational standpoint alone, it will allow both researchers and readers to clarify meanings of certain phenomena, variables, and terms used as building blocks for hypotheses, research questions, and theoretical frameworks. This tool will also provide means to elucidate nuances...
Editor,
As a new grad, I found the idea of adding a glossary section to your journal to be insightful and encouraging. Just from an operational standpoint alone, it will allow both researchers and readers to clarify meanings of certain phenomena, variables, and terms used as building blocks for hypotheses, research questions, and theoretical frameworks. This tool will also provide means to elucidate nuances and obscurities by setting certain limitations which allows for a common focus.
The review by Britton and McKee(1) asserts a general causal relationship
between episodes of high dose alcohol intake (binge drinking) and
cardiovascular deaths, based on universal physiological mechanisms. They
claim that this causal relationship explains the dramatic fluctuations in
cardiovascular deaths in Russia and (less dramatic ones) in Poland. We
could not agree more that an assessment of the patte...
The review by Britton and McKee(1) asserts a general causal relationship
between episodes of high dose alcohol intake (binge drinking) and
cardiovascular deaths, based on universal physiological mechanisms. They
claim that this causal relationship explains the dramatic fluctuations in
cardiovascular deaths in Russia and (less dramatic ones) in Poland. We
could not agree more that an assessment of the pattern of drinking should
be included in future studies, but we recommend caution in interpreting
the evidence presented in their review.
First, the definitions of binge drinking used in the studies included
in the review vary widely, and some of them probably do not represent a
distinct population of binge drinkers, such as ‘unable to perform job
properly' or ‘being registered as a heavy abuser'. Studies using such
heterogenous definitions of exposure are not "combinable".(2) These
unreliable definitions do not distinguish between binge drinkers and
regular heavy drinkers or dependent moderate drinkers, all of which are
treated as quite separate populations in their review of mechanisms for
cardiac mortality.(3) Combining these studies cannot, in our view, answer
the question whether binge drinking is related to cardiovascular deaths.
Second, it is far from clear to which extent the reviewed studies
controlled for important confounding factors. It is very likely that
people who were "unable to perform their job properly" or were registered
as "heavy abusers" also differed from the reference group in many factors
that confound the association with cardiovascular disease. Poor diet and
malabsorption of nutrients, unsatisfactory employment and social
exclusion, low educational achievement, chain smoking or inadequate
housing could all co-vary with episodes of high dose alcohol intake. It
is unlikely that all such factors could adequately be taken into account
by adjusting for a limited set of variables.
Third, the specificity of the association between binge drinking and
sudden deaths is problematic. The reference cited to support this point in
fact examined sustained heavy drinking, rather than binge drinking.(4)
Sustained heavy drinking is rare in Russia.(5)
Given all these problems, the statement that the association is
"strong and consistent" and "fulfills the criteria of causality" is
misleading. There is simply not enough evidence for this.
The origins of the hypothesis that binge increases the risk of
cardiovascular death are based on the mortality crisis in Russia. However,
it ignores the important dissociation between the mortality trends in men
and women and the gender gap in drinking. All data from Russia are
consistent in one aspect: men drink much more than women (in fact women in
Russia drink relatively little compared to the UK).(5) However, the
magnitude of cardiovascular mortality fluctuations has been the same,
proportionately, for men and women in Russia.(6) Given the consistently low
consumption in women, it is difficult to see how the massive mortality
changes could caused primarily by alcohol.(7) This is critical to the
argument of Britton and McKee because the hypothesis they developed had
the initial aim of explaining the massive mortality changes in Russia.
To date, we are aware of two prospective cohort studies on alcohol
and mortality in Russia, neither of which provide any support for the
hypothesis. In the Russian Lipid Research Clinic Study cohort, there was
no suggestion of an increased mortality in the highest category of alcohol
intake (which, given the drinking pattern common in Russia, would probably
include binge drinking).(8) In our analysis of the Novosibirsk MONICA
cohort, binge drinking (measured as the average alcohol intake on typical
occasion) was related to increased risk of death from injuries and
accidents but not from cardiovascular disease (submitted manuscript). In
the light of the present evidence, it is not likely that binge drinking
can explain the paradox of high cardiovascular mortality in Eastern
Europe, certainly not on the scale proposed by the reviewers. Acute
effects of alcohol may include some cardiovascular deaths but it is
unlikely that binge drinking caused the several hundred thousand extra
cardiovascular deaths that occurred above the long term rates in Russia
between 1987 and 1994.(6)
No one would dispute the gravity of the health crisis in Eastern
Europe or the harmful effects of drinking on many health outcomes.
However, the current state of knowledge does not (yet?) justify the
conclusion that binge drinking causes large numbers of deaths from
cardiovascular disease.
Martin Bobak
Department of Epidemiology and Public Health University College London 1-19 Torrington Place London WC1E 6BT, UK
Woody Caan
Directorate of Public Health Barking and Havering Health Authority
London, UK
References
1 Britton A, McKee M. The relation between alcohol and cardiovascular
disease in Eastern Europe: explaining the paradox. J Epidemiol Comm Health
2000;54:328-332.
2 Egger M, Smith GD, Phillips AN. Meta-analysis: principles and
procedures. BMJ 1997;315:1533-1537.
3 McKee M, Britton A. The positive relationship between alcohol and
heart disease in eastern Europe: potential physiological mechanisms. J R
Soc Med 1998;91:402-407.
5 Bobak M, McKee M, Rose R, et al. Alcohol consumption in a
national sample of the Russian population. Addiction 1999;94:857-866.
6 Leon DA, Chenet L, Shkolnikov V, et al. Huge variation in Russian mortality rates 1984-94: artefact,
alcohol, or what? Lancet 1997;350:383-388.
7 Bobak M, Marmot M. Alcohol and mortality in Russia: is it different
than elsewhere? Ann Epidemiol 1999;9:335-338.
8 Deev A, Shestov D, Abernathy J, et al.
Association of alcohol consumption to mortality of middle aged US and
Russian men and women. Ann Epidemiol 1998;8:147-153.
Dear Editor,
Global surveillance in chronic or acute infectious are really important issues.Working in the area of pidemiology in one of the least developed country, one important issue that remains for me is to strengthen the system to collect, analyse and report data scientifically, so that magnitude can be measured quantitatively,rather than the subjective impressions of professionals.
Do we have enough in...
Editor,
The results of this study may be interesting but when one considers that junior ranks (e.g. privates) make up the majority of the British armed forces then I do not believe that this represents the true figures.
If these results were taken from the original contact list as supplied by the Ministry of Defence, then there are questions related to the sample group. I believe that one of the o...
Editor,
As a new grad, I found the idea of adding a glossary section to your journal to be insightful and encouraging. Just from an operational standpoint alone, it will allow both researchers and readers to clarify meanings of certain phenomena, variables, and terms used as building blocks for hypotheses, research questions, and theoretical frameworks. This tool will also provide means to elucidate nuances...
The review by Britton and McKee(1) asserts a general causal relationship between episodes of high dose alcohol intake (binge drinking) and cardiovascular deaths, based on universal physiological mechanisms. They claim that this causal relationship explains the dramatic fluctuations in cardiovascular deaths in Russia and (less dramatic ones) in Poland. We could not agree more that an assessment of the patte...
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