You are here

  • Home
  • Online First
  • Causal links between socioeconomic status, leisure sedentary behaviours and gastro-oesophageal reflux disease: a multivariable two-sample Mendelian randomisation study

Article Text

Article menu
Download PDFPDF
Original research
Causal links between socioeconomic status, leisure sedentary behaviours and gastro-oesophageal reflux disease: a multivariable two-sample Mendelian randomisation study
  1. Xingji Lian1,2,
  2. Yifen Lin3,
  3. Xiaohui Peng1,2,
  4. Yanhui Wang1,2,
  5. Ting He1,2,
  6. Ziyong He1,2,
  7. Wenlong Gu1,2,
  8. Hongwu Wang1,2,
  9. Feng He2,4,
  10. Yuyu Huang1,2
  1. 1Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou, Guangdong, China
  2. 2School of Medicine, South China University of Technology, Guangzhou, Guangdong, China
  3. 3Department of Cardiology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China
  4. 4Department of Nephrology, Guangzhou First People's Hospital, Guangzhou, Guangdong, China
  1. Correspondence to Dr Yuyu Huang, Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, Guangzhou, Guangdong, China; yuyuhuang{at}yeah.net; Professor Feng He; eyhefeng{at}scut.edu.cn

Abstract

Introduction We implemented a two-sample multivariable Mendelian randomisation (MR) analyses to estimate the causal effect of socioeconomic status and leisure sedentary behaviours on gastro-oesophageal reflux disease (GERD).

Methods Independent single-nucleotide polymorphisms associated with socioeconomic status and leisure sedentary behaviours at the genome-wide significance level from the Medical Research Council Integrative Epidemiology Unit (MRC-IEU) UK Biobank were selected as instrumental variables. Summary-level data for GERD were obtained from a recent publicly available genome-wide association involving 78 707 GERD cases and 288 734 controls of European descent. Univariable and multivariable two-sample MR analyses, using inverse variance weighted method for primary analyses, were performed to jointly evaluate the effect of socioeconomic status and leisure sedentary behaviours on GERD risk.

Results Three socioeconomic status, including educational attainment (OR 0.46; 95% CI 0.30 to 0.69; p<0.001), average total household income before tax (OR 0.65; 95% CI 0.47 to 0.90; p=0.009) and Townsend Deprivation Index at recruitment (OR 1.60; 95% CI 1.06 to 2.41; p=0.026), were independently and predominately responsible for the genetic causal effect on GERD. In addition, one leisure sedentary behaviour, such as time spent watching television, was independently and predominately responsible for genetic causal effect on GERD (OR 3.74; 95% CI 2.89 to 4.84; p<0.001). No causal effects of social activities and driving on GERD were observed.

Conclusions Genetically predicted Townsend Deprivation Index at recruitment and leisure watching television were causally associated with increased risk of GERD, and age at completion of full-time education and average total household income before tax were causally associated with decreased risk of GERD.

  • GASTROENTEROLOGY
  • ECONOMICS
  • SOCIAL CLASS
  • LIFE STYLE

Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information.

http://dx.doi.org/10.1136/jech-2023-220311

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Data availability statement

    All data relevant to the study are included in the article or uploaded as online supplemental information.

    View Full Text

    Footnotes

    • Contributors XL and YL contributed equally to this paper. YH and FH share joint correspondence in this work. XL, FH and YH designed the study question. YL, XP, YW, TH, ZH, WG and HW conducted the acquisition of data, analysis and interpretation of data. XL and YL conducted the analyses. XL wrote the first draft of the paper. YH took responsibility for the overall content of the article, having access to the data, and controlling the decision to publish. XL, FH and YH interpreted the data. All authors critically reviewed the manuscript and approved submission of the final manuscript.

    • Funding The research was funded by grants from the Guangzhou Key Discipline of Medicine (Geriatric Medicine, ZDXK202103) and Science and Technology Projects in Guangzhou (202102010017).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.