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Effort–reward imbalance and long-term benzodiazepine use: longitudinal findings from the CONSTANCES cohort
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  • Published on: 4 January 2024
    Re: Effort-reward imbalance and long-term benzodiazepine use: longitudinal findings from the CONSTANCES cohort

    Airagnes et al. examined the association between effort–reward imbalance and incident long-term benzodiazepine use (LTBU) (1). The effort–reward imbalance was calculated in quartiles, and the adjusted odds ratios (95% confidence intervals) of the third and fourth quartiles of effort-reward imbalance for incident LTBU over a 2-year follow-up period were 1.74 (1.17 to 2.57) and 2.18 (1.50 to 3.16), respectively. They also clarified a dose-dependent relationship and an
    interaction of tobacco smoking on the relationship. I have a comment with special reference to the number of subjects with LTBU during follow-up in each sex.

    About two thirds of subjects with LTBU during follow-up were women. The same authors reported that the prevalence of long-term prescribed benzodiazepine use in the French population was 2.8% in men and 3.8% in women in the year 2015 (2). Although the total percentage of subjects with LTBU during follow-up was under 1%, there are differences in the long-term prescription percentage between men and women. As the authors observed the interaction of tobacco smoking on the relationship, I recommend the additional analysis, which should be stratified by sex, according to their previous cross-sectional study (3).

    References
    1. Airagnes G, Lemogne C, Kab S, et al. Effort-reward imbalance and long-term benzodiazepine use: longitudinal findings from the CONSTANCES cohort. J Epidemiol Community Health. 2019 Nov;73(11):993-1001.
    2. Aira...

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    Conflict of Interest:
    None declared.