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P129 Downward dementia trend goes into reverse in England and Wales? English Longitudinal Study of Ageing 2002 to 2019
  1. Yuntao Chen1,
  2. Piotr Bandosz2,
  3. George Stoye3,
  4. Yuyang Liu4,
  5. Yanjuan Wu4,
  6. Sophia Lobanov-Rostovsky1,
  7. Eric French5,
  8. Mika Kivimaki6,
  9. Gill Livingston6,
  10. Jing Liao4
  1. 1Department of Epidemiology and Public Health, University College London, London, UK
  2. 2Division of Prevention Medicine and Education, Medical University of Gdansk, Gdansk, Poland
  3. 3Institute for Fiscal Studies, London, UK
  4. 4Department of Medical Statistics, Sun Yat-sen University, Guangzhou, China
  5. 5Faculty of Economics, University of Cambridge, Cambridge, UK
  6. 6Division of Psychiatry, University College London, London, UK


Background Recent evidence suggests dementia incidence rates are declining in high-income countries. However, data for the trend after 2010 are scarce. We examined the temporal trend in England and Wales from 2002–2019, considering bias and non-linearity.

Methods We used population-based panel data linked to the mortality register across wave 1 (2002–2003) to wave 9 (2018–2019) of the English Longitudinal Study of Ageing, representing initially non-institutionalised adults ≥50 years old. Uniform standard criteria based on cognitive and functional impairment were used to ascertain incident dementia cases. Crude incidence rates were determined in seven overlapping initially dementia-free sub-cohorts followed over four years. We examined the temporal trend of dementia incidence according to age, sex and education attainment. We estimated the age- and sex-adjusted trend of dementia incidence with Cox and multi-state models. Restricted cubic splines allowed for potential non-linearity.

Results 19 806 people were included in the study. Crude dementia incidence declined from 2002 to 2008 (8.7 to 7.4 per 1000 person-years). The rate increased from 2008 to 2019 (7.4 to 10.3 per 1000 person-years). Adjusting for age and sex, and accounting for missing dementia cases due to death, estimated dementia incidence declined by 28.8% from 2002 to 2008 (incidence rate ratio 0.71, 95% CI 0.58–0.88), and increased by 25.2% from 2008 to 2016 (incidence rate ratio 1.25, CI 1.03–1.54). The higher education group had a sharper decline of dementia incidence from 2002 to 2008, and a smaller increase after 2008.

Conclusion Dementia incidence may not be declining. There was a rebound after 2008 in England and Wales. If the upward dementia incidence trend continues, along with population ageing, the burden on health and social care may be large. The burden may be considerably larger than estimated on the basis of a linearly declining dementia incidence trend.

  • dementia incidence
  • temporal tremd
  • non-linearity

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