Article Text
Abstract
Background The association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.
Methods Pooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.
Results For the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).
Conclusions These findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.
- socioeconomic
- cancer: occupational
- cancer epidemiology
Data availability statement
Data are available upon reasonable request. Data are available from the corresponding author, DIC, upon reasonable request, with the permission of the INHANCE Consortium.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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Data availability statement
Data are available upon reasonable request. Data are available from the corresponding author, DIC, upon reasonable request, with the permission of the INHANCE Consortium.
Supplementary materials
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Footnotes
Twitter @davidiconway
Deceased Dr Isabelle Stucker is since deceased.
Contributors DIC conceived the study. DIC, ADM, TB, JH, AR and WA designed the study. JH with ADM and TB performed analysis. MH and ALY-C coordinated pooled data. All authors (DIC, JH, WA, AR, IH, PL, DS, CC, LR, CH, KK, GJM, PT, AA, AZ, PB, DL, GM, IS, SB, HR, PB, MV, LF, MPC, AM, AD, RK, VW-F, ALY-C, MH, TB, ADM) reviewed analysis proposal and plan. DIC, TB, JH, AR and ADM drafted the manuscript. All authors read and reviewed the final manuscript. DIC is responsible for the overall content as guarantor.
Funding This work was supported by funders of the original studies. ARCAGE (Western Europe): European Community (5th Framework Programme) grant no QLK1-CT-2001-00182; France study: Swiss League against Cancer (KFS1069-09-2000), Fribourg League against Cancer (FOR381.88), Swiss Cancer Research (AKT 617) and Gustave-Roussy Institute (88D28); Germany-Heidelberg study: German Ministry of Education and Research (No. 01GB9702/3); Latin American study: Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina, IMIM (Barcelona), Fundaco de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) (No. 01/01768-2), and European Commission (IC18-CT97-0222); INHANCE Pooled Data Project: NCI (R03CA113157, NIDCR R03DE016611). ICARE (France 2001–2007): French National Research Agency (ANR); French National Cancer Institute (INCA); French Agency for Food, Environmental and Occupational Health and Safety (ANSES); French Institute for Public Health Surveillance (InVS); Fondation pour la Recherche Médicale (FRM); Fondation de France; Fondation ARC pour la Recherche sur le Cancer; French Ministry of Labour (Direction Générale du Travail); French Ministry of Health (Direction Générale de la Santé).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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