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Periodontopathogens antibodies and major adverse events following an acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI)
  1. A Boillot1,2,
  2. H Range1,3,
  3. N Danchin4,5,
  4. S Kotti6,
  5. G Cosler3,
  6. S Czernichow2,7,
  7. O Meilhac8,9,
  8. E Puymirat4,5,
  9. M Zeller10,
  10. D Tchetche11,
  11. P Bouchard1,12,
  12. T Simon3,6,13
  1. 1Department of Periodontology, Rothschild Hospital (AP-HP); UFR of Odontology, University of Paris Diderot, Paris, France
  2. 2INSERM UMRS 011, Population-based Cohort Platform, Villejuif, France
  3. 3INSERM UMRS 1148, Laboratory for Vascular Translational Science, Paris, France
  4. 4Department of Cardiology, AP-HP, Georges Pompidou European Hospital, Paris, France
  5. 5University of Paris-Descartes, Paris, France
  6. 6Assistance Publique-Hôpitaux de Paris (APHP), St Antoine Hospital, URC-EST, Paris, France
  7. 7Department of Nutrition, Ambroise Paré Hospital (AP-HP), University of Versailles Saint Quentin en Yvelines, Boulogne-Billancourt, France
  8. 8INSERM UMRS 1188, Diabète athérothrombose Thérapies Réunion Océan Indien, Sainte Clotilde, La Réunion, France
  9. 9La Réunion University, Sainte Clotilde, La Réunion, France
  10. 10Department of Cardiology, Dijon University Hospital, Dijon, France
  11. 11Department of Cardiology, Clinique Pasteur, Toulouse, France
  12. 12EA 2496, UFR of Odontology, University of Paris Descartes, Montrouge, France
  13. 13Department of Clinical Pharmacology, University of Pierre et Marie Curie, Paris, France
  1. Correspondence to Professor P Bouchard, Department of Periodontology, Rothschild Hospital (AP-HP); UFR of Odontology, University of Paris Diderot, 5 rue Garancière, Paris 75006, France; phbouch{at}


Background Periodontopathogens antibodies have been shown to be associated with primary myocardial events, but little is known regarding their impact on major adverse events after a prior acute myocardial infarction (AMI). The present prospective study evaluates the association between antibody levels of 4 periodontopathogens and the risk of all-cause death or non-fatal myocardial infarction (MI) at 1 year in 975 patients admitted for acute ST segment or non-ST segment elevation MI in French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI), a nationwide French survey.

Methods Multiserotype ELISAs were performed to assess levels of IgG and IgA against Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Tannerella forsythia.

Results Adjusted HRs indicate the lack of association between IgG-anti-Po. gingivalis levels (0.96 (0.78 to 1.18)), IgA-anti-Po. gingivalis levels (1.13 (0.90 to 1.42)) and the risk of all-cause death or non-fatal MI at 1 year. Additionally, no significant association was found between the occurence of an event at 1 year and immunoglobulins levels against the others periodontopathogens.

Conclusions The present data indicate that circulating levels of periodontopathogens antibodies are not associated with an increased risk of major adverse events in patients with a prior AMI. Studies dealing with bacterial and clinical data are needed to assess the role of oral health in comprehensive cardiac rehabilitation programmes.

  • Cardiovascular disease
  • Cohort studies
  • Epidemiology of cardiovascular disease

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  • AB and HR contributed equally.

  • Contributors AB, HR, ND, SK, TS, PB, SC and OM contributed to the planning of the work described in the manuscript. ND, TS, HR, EP, DT, GC and MZ contributed to the conduct of the study. AB, HR, SK, TS, PB, SC and OM contributed to the reporting of the study.

  • Funding FAST-MI is a registry of the French Society of Cardiology, supported by unrestricted grants from Pfizer and Servier and a research grant from the French Caisse Nationale d'Assurance Maladie. The multiserotype ELISA were also supported by a grant from Colgate–Palmolive Europe.

  • Competing interests None declared.

  • Ethics approval All procedures performed in this study involving human participants were in accordance with the ethical standards of the Committee for the Protection of Human Subjects in Biomedical Research of Saint Antoine University Hospital and the data file was declared to the ‘Commission Nationale Informatique et Liberté’ (CNIL) and with the 1964 Helsinki declaration and its later amendments.

  • Provenance and peer review Not commissioned; externally peer reviewed.