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STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement
  1. Valentina Gallo1,2,
  2. Matthias Egger3,
  3. Valerie McCormack4,
  4. Peter B Farmer5,
  5. John P A Ioannidis6,7,
  6. Micheline Kirsch-Volders8,
  7. Giuseppe Matullo9,10,
  8. David H Phillips11,
  9. Bernadette Schoket12,
  10. Ulf Stromberg13,
  11. Roel Vermeulen14,
  12. Christopher Wild4,
  13. Miquel Porta15,
  14. Paolo Vineis1,9
  1. 1Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
  2. 2Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, UK
  3. 3Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland
  4. 4International Agency for Research on Cancer, Centre International de Recherche sur le Cancer (IARC) Lyon, France
  5. 5Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
  6. 6Stanford Prevention Research Centre, Stanford University School of Medicine, Stanford, USA
  7. 7Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
  8. 8Laboratory for Cell Genetics, Vrije Universiteit Brussel, Brussels, Belgium
  9. 9HuGeF Human Genetics Foundation, Turin, Italy
  10. 10Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
  11. 11Institute of Cancer Research, Sutton, UK
  12. 12National Institute of Environmental Health, Budapest, Hungary
  13. 13Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
  14. 14Institute for Risk Assessment Sciences (IRAS), Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
  15. 15Institut Municipal d'Investigacio Medica (IMIM), Universitat Autonoma de Barcelona, Barcelona, Spain
  1. Correspondence to Dr Valentina Gallo, MD, LSHTM-MSc, Research Associate, School of Public Health, Imperial College London, St Mary's Campus, Norfolk place, W2 1PG London, UK


Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility, and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and the body components or processes. The need for improved reporting of scientific research led to influential statements of recommendations such as STrengthening Reporting of Observational studies in Epidemiology (STROBE) statement. The STROBE initiative established in 2004 aimed to provide guidance on how to report observational research. Its guidelines provide a user-friendly checklist of 22 items to be reported in epidemiological studies, with items specific to the three main study designs: cohort studies, case-control studies and cross-sectional studies. The present STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE Statement implementing 9 existing items of STROBE and providing 17 additional items to the 22 items of STROBE checklist. The additions relate to the use of biomarkers in epidemiological studies, concerning collection, handling and storage of biological samples; laboratory methods, validity and reliability of biomarkers; specificities of study design; and ethical considerations. The STROBE-ME recommendations are intended to complement the STROBE recommendations.

  • Epidemiology
  • molecular epidemiology
  • biomarkers
  • validation
  • reporting recommendations
  • neuroepidemiology
  • molecular epidemiology

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  • This article is being simultaneously published in 2011 in PLoS Medicine, Journal of Clinical Epidemiology, Preventive Medicine, Mutagenesis, Journal of Epidemiology and Community Health, European Journal of Epidemiology and European Journal of Clinical Investigation. Reproduced by permission of the authors.

  • Funding This paper is part of an activity sponsored by the ECNIS network (EC grant FOOD-CT-2005-513943) (

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.