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4.4 PharmacoepidemiologyChair: Dr. John Frank, Canada
O4-4.1 Non-steroidal anti-inflammatory drug and aspirin use and the risk of head and neck cancer
  1. J C Wilson1,
  2. L Murray1,
  3. C Hughes1,
  4. A Black2,
  5. L Anderson1
  1. 1Queen's University Belfast, Belfast, UK
  2. 2National Cancer Institute, Bethesda, Maryland, USA


Introduction The use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with a reduced risk of several cancers. Evidence for NSAIDs preventing head and neck cancer (HNC) is inconclusive. We conducted a prospective cohort study to examine the association between NSAID use and HNC risk.

Methods Using data from the National Cancer Institute (NCI) Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, we examined the association between aspirin / NSAID use and HNC incidence among 142 034 men and women aged 55–74 years. Information regarding regular use and frequency of use of aspirin and NSAIDs over the last 12 months was reported at enrolment. (1993–2001). Individuals were followed-up until 2006. HRs and 95% CIs were calculated using multivariable cox proportional hazards regression with adjustment for potential confounders including tobacco use, gender, body mass index and age.

Results Over the follow-up period 316 individuals were diagnosed with HNC. Regular aspirin use, compared to non-use, was associated with a significantly reduced incidence of HNC (Adjusted HR 0.78; 95% CI 0.62 to 0.98). No association was observed with regular NSAID use, compared to non-use, and HNC incidence (adjusted HR 0.99, 95% CI 0.76 to 1.28).

Conclusions Our study suggests that aspirin may have potential as a chemopreventative agent for HNC however further investigation is warranted.

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