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Global problems
P2-393 Cardiovascular and diabetes risk in persons with early glucose metabolism impairments
  1. T Dzebisashvili
  1. Moscow Regional Research Clinical Institute named by M.F.Vladimirskiy, Moscow, Russia


Aim To assess RR of type 2 diabetes (T2DM), overall and acute cardiovascular mortality and cardiovascular events in persons with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).

Materials and Methods According to population based study among 2508 adults, 3-year risk of T2DM, overall and acute cardiovascular mortality and cardiovascular events (myocardial infarction and stroke, coronary heart disease) was estimated in people with IFG, IGT, IFG+IGT diagnosed in 2006 in comparison with normal glucose tolerance. RR and regression coefficient (B) was calculated. RR of T2DM, cardiovascular events was adjusted for age, sex, BMI, systolic blood pressure, smoking.

Results Highest percent of transformation to T2DM and adjusted RR of T2DM was in IFG+IGT (33.3% and 11.2 [3.93–31.65], p<0.01). Lowest percent of transformation to T2D and RR of T2DM was in isolated IGT (10.3% and 3.92 [1.11–13.90], p=0.034). Adjusted RR of cardiovascular mortality was significantly 3.2-fold higher in IFG. IGT and newly diagnosed T2D had significantly 3.6-fold and 2.3-fold greater risk of overall mortality. RR of cardiovascular events was significantly increased 2.2-fold in IFG and 2.7-fold in newly diagnosed T2D. There was not linear association between blood glucose levels and cardiovascular mortality risk (p=0.095) in contrast to the continuous linear relationship observed between blood glucose levels and coronary heart disease risk B=0.273 (p=0.001).

Conclusion 3-year risk of developing T2DM is not equal at different early glucose metabolism impairments. IFG increased 3-year risk of acute cardiovascular mortality. These may provide insights, that hyperinsulinemia influence on acute cardiovascular mortality risk.

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