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Chronic disease
P2-289 Obesity and whole blood serotonin in healthy volunteers
  1. S J Hodge,
  2. B P Bunting,
  3. J J Strain,
  4. B J Stewart-Knox
  1. University of Ulster, Coleraine, UK


The aim of this study was to explore associations between fasting whole blood serotonin levels and anthropometric measures in healthy male and female volunteers (N=68) aged between 20 and 66 years. A fasting (20 ml) venous blood sample for whole blood serotonin was collected, after which body mass index and waist circumference (WC) were measured by DEXA (dual energy x-ray absorptiometry) scan. Data were analysed using the SPSS (Statistical Package for the Social Sciences v 17.0) software. Pearson (partial) correlations showed significant associations between whole blood serotonin and BMI (r=−0.284, p=0.021) and waist circumference (r=−0.325, p=0.008). The correlational nature of these analyses do not enable conclusions to be drawn as to cause and effect but suggest an interplay between obesity and lower whole blood serotonin levels.

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  • Funding This analysis has been funded by the HRB (Ireland) Health Research Centre.