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Chronic disease
P2-277 Alcohol drinking and primary liver cancer in Japanese: a pooled analysis of four cohort studies
  1. T Shimazu1,
  2. S Sasazuki1,
  3. K Wakai2,
  4. A Tamakoshi3,
  5. I Tsuji4,
  6. Y Sugawara4,
  7. K Matsuo5,
  8. C Nagata6,
  9. T Mizoue7,
  10. K Tanaka8,
  11. M Inoue1,
  12. S Tsugane1
  1. 1National Cancer Center, Tokyo, Japan
  2. 2Nagoya University Graduate School of Medicine, Nagoya, Japan
  3. 3Aichi Medical University School of Medicine, Aichi, Japan
  4. 4Tohoku University Graduate School of Medicine, Sendai, Japan
  5. 5Aichi Cancer Center Research Institute, Nagoya, Japan
  6. 6Gifu University Graduate School of Medicine, Gifu, Japan
  7. 7National Center for Global Health and Medicine, Tokyo, Japan
  8. 8Saga University, Saga, Japan


Introduction Because studies of the association between alcohol intake and the risk of primary liver cancer use varying cut-off points to classify alcohol intake, it is difficult to precisely quantify this association by meta-analysis of published data. Furthermore, there are limited data for women in prospective studies of the dose-specific relation of alcohol intake and the risk of primary liver cancer.

Methods We analysed original data from four population-based prospective cohort studies encompassing 174 719 participants (89 86 men and 84 856 women). After adjustment for a common set of variables, we used Cox proportional hazards regression to estimate HRs and 95% CIs of primary liver cancer incidence according to alcohol intake. We conducted a meta-analysis of the HRs derived from each study.

Results During 1 964 136 person-years of follow-up, 804 primary liver cancer cases (605 men and 199 women) were identified. In male drinkers, the multivariate-adjusted HRs (95% CI) for alcohol intakes of 0.1–22.9, 23.0–45.9, 46.0–68.9, 69.0–91.9, and ≥92.0 g/day, as compared with occasional drinkers, were 0.88 (0.57 to 1.36), 1.06 (0.70 to 1.62), 1.07 (0.69 to 1.66), 1.76 (1.08 to 2.87), and 1.66 (0.98 to 2.82), respectively (p for trend=0.015). In women, we observed a significantly increased risk among those who drank ≥23.0 g/day, as compared with occasional drinkers (HR: 3.60; 95% CI 1.22 to 10.66).

Conclusion This pooled analysis of data from large prospective studies in Japan indicates that avoidance of (1) heavy alcohol drinking (≥69.0 g alcohol/day) in men and (2) moderate drinking (≥23.0 g alcohol/day) in women may reduce the risk of primary liver cancer.

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