Introduction Little is known about the association between the metabolic syndrome (MetS) and cervical cancer carcinogenesis.
Methods The Me-Can cohort includes 288 834 women. During an average follow-up of 11 years 425 invasive cervical cancer cases were diagnosed. HRs were estimated by use of Cox proportional hazards regression models for quintiles and standardised z-scores (with a mean of 0 and a SD of 1) of body mass index, blood pressure, glucose, cholesterol, triglycerides and a MetS score. Risk estimates were corrected for random error in the measurements.
Results The MetS score was associated with increased risk of cervical cancer (per 1 SD increase, HR, 1.26; 95% CI 1.08 to 1.47). Among individual metabolic factors, associations were observed for BMI (per 1 SD increase, 1.12; 1.01 to 1.25), blood pressure (1.25; 1.04 to 1.49), and triglycerides (1.39; 1.15 to 1.68). In models including all metabolic factors simultaneously, the associations for blood pressure and triglycerides persisted. Stratification by morphology showed stronger association of triglycerides with squamous cell carcinoma (SCC) (1.42; 95% CI1.09 to 1.84) than with adenocarcinoma (ADC) (0.97, 0.53 to 1.75). Among older women cholesterol (50–70 years HR, 1.34; 95% CI 1.00 to 1.81), triglycerides (50–70 years HR 1.49, 95% CI 1.03 to 2.16 and ≥70 years HR 1.53, 95% CI 1.08 to 2.17) and glucose (≥70 years HR 1.87, 95% CI 1.12 to 3.12) concentrations were associated with cervical cancer.
Conclusions The results of this large prospective study provide evidence for an association between cervical cancer and the MetS as well as the individual MetS factors including BMI, blood glucose and triglyceride levels.
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