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Chronic disease
P2-118 Vitamin C intake from diary recordings and risk of breast cancer in the UK dietary cohort consortium
  1. J Hutchinson1,
  2. M Lentjes2,
  3. D Greenwood3,
  4. V Burley1,
  5. J Cade1,
  6. C Cleghorn1,
  7. D Threapleton1,
  8. T Key4,
  9. B Cairns4,
  10. R Keogh5,6,
  11. C Dahm6,7,
  12. E Brunner8,
  13. M Shipley8,
  14. D Kuh9,
  15. G Mishra9,
  16. A Stephen10,
  17. A Bhaniani2,
  18. G Borgulya2,
  19. K T Khaw2,
  20. S Rodwell6
  1. 1Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK
  2. 2Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  3. 3Centre of Epidemiology and Biostatistics, University of Leeds, Leeds, UK
  4. 4Cancer Epidemiology Unit, University of Oxford, Oxford, UK
  5. 5MRC Biostatistics Unit, Institute of Public Health, University of Cambridge, Cambridge, UK
  6. 6MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  7. 7Department of Cardiology, Aarhus University Hospital, Aalborg, Denmark
  8. 8Department of Epidemiology and Public Health, University College London, London, UK
  9. 9MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, London, UK
  10. 10MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK


Introduction Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires. No study has assessed this relationship prospectively using food diaries which may more accurately measure intake.

Methods Estimated dietary vitamin C intake was derived from 4 to 7 day food diaries pooled from five prospective studies in the UK Dietary Cohort Consortium. This nested case-control study of 851 incident breast cancer cases and 2727 matched controls examined breast cancer risk in relation to dietary vitamin C intake using conditional logistic regression adjusting for relevant covariates. Additionally, total vitamin C intake from supplements and diet was analysed in the three largest cohorts.

Results No evidence of an association was observed between breast cancer risk and dietary (OR=1.00 per 60 mg/d, 95% CI 0.91 to 1.09, Ptrend=1.0) or total vitamin C intake (OR=1.01 per 60 mg/d, 95% CI 1.00 to 1.03, Ptrend=0.1) in analyses using continuous estimates or by fifths of intake. Additionally, there was no association for post-menopausal women.

Conclusions This pooled analysis of individual UK women found no evidence of associations between breast cancer incidence and dietary or total vitamin C intake derived uniquely from detailed diary recordings.

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