Introduction We carried out a meta-analysis to determine the association between exposure to PD and ischaemic CDH.

Material and methods Studies published case-control between 1999 and 2009 were obtained from the search site PUBMED/MEDLINE, Lilacs e Google. The articles included report results of observational studies, case-control on the association between PD and DCVI, where the DP should have been diagnosed by clinical parameters that included probing depth (PD) and clinical attachment level (NIC) DCVI and was represented by one of the following outcomes: Coronary Artery Disease (CAD), Myocardial Infarction (AMI) with or without angina pectoris, or Acute Coronary Syndrome (ACS). The quality of the articles was assessed using criteria recommended in “The Strengthening the Reporting of Observational Studies in Epidemiology-STROBE”. In addition, compliance with the guidelines of the guide to meta-analysis for observational studies-MOOSE.

Results Of the 23 studies, case-control eligible, 16 had their results combined using the methodology of meta-analysis. The overall OR was approximately 2.52 (95% CI 2109 to 3009, p<0.001), indicating that individuals with PD have an increased chance of developing ischaemic CDH as compared to those without PD.

Conclusion Observational case-control suggest that individuals with PD are more likely to develop ischaemic CDH, however, further studies are needed for more definitive conclusions.