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Chronic disease
P2-12 Recurrent denture related sores and oral cancer
  1. L D B Rotundo1,
  2. T N Toporcov2,
  3. M G Haye Biazevic1,
  4. M B de Carvalho3,2,
  5. J L Ferreira Antunes2
  1. 1Faculdade de Odontologia, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  2. 2Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo,Sao Paulo, Brazil
  3. 3Hospital Heliopolis, Sao Paulo, Sao Paulo, Brazil


Background The potential contribution of denture-related sores to oral carcinogenesis still fuels controversies. This study assessed the association between recurrent denture-related sores and squamous cell carcinoma in anatomic sites of the mouth that are specifically at risk of sores by ill-fitting dentures.

Methods We conducted a hospital-based case-control study comprising 71 histologically-confirmed cases of squamous cell carcinoma in anatomic sites of the mouth that were specifically at risk of developing sores due to ill-fitting dentures, who were attended at two hospitals in São Paulo, Brazil; and 240 controls without cancer, recruited from outpatient units of the same hospitals. Associations were assessed by multivariate logistic regression conditioned on socio-demographic (family income) and behavioural characteristics (tobacco smoking, alcohol drinking and dietary patterns).

Results The association between ill-fitting dentures and mouth cancer was statistically significant in the multivariate model, which adjustment for socio-demographic and behavioural characteristics: OR=3.98 (95% CI 1.06 to 14.96). The specific assessment of association between tumours in the lower jaw and sores by mandibular dentures confirmed this result (OR=6.39; 95% CI 1.49 to 29.52).

Conclusions These results reinforce the hypothesis that an appropriate application and monitoring of dental prosthesis represent a non-negligible scope for cancer prevention.

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