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P1-537 Retinopathy of prematurity and neonatal risk factors: a retrospective cohort study
  1. H Hoseini1,
  2. Z Asadi1,
  3. H Tolide-ie2,3,
  4. S Kowsarnia1
  1. 1Department of Ophthalmology, Poostchi Ophthalmic Research Center, Shiraz, Iran
  2. 2Gonabad University of Medical Sciences, Gonabad, Iran
  3. 3Shiraz Burn Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


Introduction Recent technological advances in neonatology have increased the survival rate of very low birth weight infants, which has led to a correspondingly increased incidence of retinopathy of prematurity (ROP).

Objective To identify neonatal risk factors for severe ROP in premature babies.

Methods A retrospective cohort study was undertaken In Shiraz from January 2006 to April 2010. All premature neonates with gestational age (GA) of <34 weeks or birth weight (BW) of <2000 g were included in the study.

Results During 5 years of study, 1095 premature infants were analysed. There were 732(66.8%) infants did not develop ROP, 363(33.2%) infants presented with various degrees of ROP (249 infants without treatment and 114 infants were treated with laser). We compared 2 groups of neonates, who were treated with laser and those who didn't received any treatment. Univariate logistic regression showed that GA [OR=0.68 (95% CI 0.62 to 0.75)], BW [OR=0.997 (95% CI 0.996 to 0.998)], length [OR=0.84 (95% CI 0.80 to 0.89)], and head circumference (HC) [OR=0.73 (95% CI 0.66 to 0.80)] had significant inverse relationships with developing ROP and there is no statistical relationship between sex of neonates and ROP (p value=0.054). However, after adjustment in multivariate logistic model, only GA and HC remained in the model as independent risk factors. Adjusted OR for H.C was 0.8 (95% CI 0.71 to 0.90) and Adjusted ORs for, GA ≤28 weeks, and, 28 weeks<GA<32 weeks, were 4.32 (95% CI 1.76 to 10.57) and 3.5 (95% CI 1.56 to 7.83) in comparison with ,GA≥32 weeks.

Conclusion Gestational age and head circumference at birth were the most important risk factors for severe ROP in our study.

  • Retinopathy of prematurity
  • neonatal risk factors
  • head circumference

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