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P1-525 Relationship between serum antioxidant vitamins and n-terminal pro-b-type natriuretic peptide in a general Japanese population
  1. K Suzuki1,
  2. J Ishii2,
  3. F Kitagawa3,
  4. A Kuno3,
  5. Y Kusuhara4,
  6. J Ochiai5,
  7. Y Ito6,
  8. N Hamajima6,
  9. T Inoue1
  1. 1Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Japan
  2. 2Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University, School of Medicine, Toyoake, Japan
  3. 3Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital, Toyoake, Japan
  4. 4Department of Medical Zoology, Fujita Health University, School of Health Sciences, Toyoake, Japan
  5. 5Department of Medical Electronics, Fujita Health University, School of Health Sciences, Toyoake, Japan
  6. 6Department of Preventive Medicine, Nagoya University, Graduate School of Medicine, Nagoya, Japan


Introduction Several epidemiological studies have demonstrated that carotenoid relate inversely to cardiovascular disease incidence. However few studies have been conducted on the relationship between circulating antioxidant vitamins and N-terminal pro-brain natriuretic peptide (NT-proBNP), a biomarker of cardiac function and heart failure, in the general population. The aim of this study was to investigate whether circulating antioxidant vitamins were independently related to NT-pro-BNP in a general Japanese population.

Methods Subjects were 1056 inhabitants (390 men and 666 women, mean age: 60.3±10.5 years) of Japan, who attended health check-up examinations from 2003 to 2004. Serum levels of carotenoids, retinol and tocopherols were separately determined by high-performance liquid chromatography. Serum NT-proBNP levels were measured by electrochemiluminescence immunoassay.

Results Geometric mean of serum NT-proBNP was significantly higher in women than in men (53.1 vs 39.1 pg/ml, p<0.001). Partial correlation analysis, adjusting for age, smoking habits, drinking habits, serum triglyceride levels, haemoglobin A1c, body mass index, systolic blood pressure, and estimated glomerular filtration rate, revealed a significant association between serum NT-proBNP levels and serum levels of retinol (r=−0.157, p<0.001), canthaxanthin (r=−0.142, p<0.001), lycopene (r=−0.106, p=0.007), α-carotene (r=−0.103, p=0.009), and β-carotene (r=−0.086, p=0.028) in women. In men, serum levels of antioxidant vitamins were not significantly related with serum NT-proBNP levels.

Conclusion Serum levels of retinol and several carotenoids were inversely associated with serum NT-proBNP levels even after adjustment for possible confounding factors in Japanese women, whereas no significant association was observed in Japanese men.

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