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Bidirectional associations between depression/anxiety and bowel disease in a population based cohort
  1. Carsten Leue1,
  2. Jim van Os1,5,
  3. Jan Neeleman2,
  4. Ron de Graaf3,
  5. Wilma Vollebergh3,
  6. R W Stockbrügger4
  1. 1Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, Netherlands
  2. 2Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
  3. 3The Netherlands Institute of Mental Health and Addiction, Trimbos Institute, Utrecht, Netherlands
  4. 4Department of Gastroenterology and Hepatology, University Hospital of Maastricht, Maastricht, Netherlands
  5. 5Division of Psychological Medicine, Institute of Psychiatry, London, UK
  1. Correspondence to:
 Professor J van Os
 Department of Psychiatry and Neuropsychology, Maastricht University, PO Box 616 (DRT 10), 6200 Maastricht, Netherlands; j.vanossp.unimaas.nl

https://doi.org/10.1136/jech.2004.028175

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    Kurina and colleagues1 reported that neurotic disorders preceded inflammatory bowel disease (IBD), adding credence to the suggestion that depression/anxiety may either play an aetiological part in the onset of IBD or that both conditions share a common abnormality.2 As their findings were based on record linkage of people with neurotic disorder who received treatment in mental health services, representing only a small minority of such cases, replication independent of mental health service treatment setting is necessary to exclude the well known bias attributable to selection of the most severely ill with the highest comorbidity rates.

    This analysis is a part of the Netherlands mental health survey and incidence study (NEMESIS), a …

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