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Long term effect of breast feeding: cognitive function in the Caerphilly cohort
  1. P C Elwood1,
  2. Janet Pickering1,
  3. J E J Gallacher1,
  4. Janie Hughes1,
  5. David Davies2
  1. 1Department of Epidemiology, Statistics and Public Health, The University of Wales College of Medicine, Cardiff, UK
  2. 2Department of Child Health, The University of Wales College of Medicine
  1. Correspondence to:
 Professor P Elwood
 MRC Unit, Llandough Hospital, Penarth CF64 2XW, UK; pelwooddoctors.org.uk

Abstract

Study objective: There is evidence suggesting that artificial feeding is associated with a reduction in cognitive function in infants and children, in contrast with breast feeding, but the available evidence suffers from confounding by social and educational factors. An opportunity arose in the Caerphilly cohort study to examine relations between cognitive function in older men and their feeding as infants, when breast feeding was usual.

Design: A prospective cohort study.

Setting: Caerphilly, South Wales, UK, was a deprived coal mining community when the men had been born in 1920–35. Most had been breast fed as infants.

Participants: 779 men aged 60–74 years when tested. The men had earlier been asked to obtain from their mothers their birth weight, and how they had been fed as infants.

Results: Complete data were obtained for 779 men. In those whose birth weight had been at or above the median, the adjusted mean cognitive function was only slightly and non-significantly lower in those who had been artificially fed. In the men whose birth weight had been below the median, having been artificially fed was associated with significantly lower results in both a test of reasoning (the AH4) and word power (the national adult reading test (NART)). Two standard deviations below the median birth weight, artificial feeding was associated with a reduction of six points (70% of a SD) on word power (the NART).

Conclusions: In men whose birth weight had been low, having been artificially fed is associated with poorer cognitive function in late adult life.

  • NART, national adult reading test
  • CRT, choice reaction time

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Footnotes

  • Funding: the Caerphilly study was conducted by the former MRC Epidemiology Unit (South Wales) and was funded by the Medical Research Council of the United Kingdom. The archive is now maintained by the Department of Social Medicine in the University of Bristol. Janet Pickering and Janie Hughes are supported by the Food Standards Agency.

  • Conflicts of interest: no author has any competing interests.

  • Ethical approval was sought and obtained from an appropriate ethics committee for every phase of the Caerphilly study

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