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Fibrinogen, social position, and risk of heart disease
  1. J Macleod1,
  2. G Davey Smith2
  1. 1Division of Primary Care, Public and Occupational Health and The Medical School Birmingham, UK
  2. 2Department of Social Medicine, University of Bristol, Bristol, UK
  1. Correspondence to:
 Dr J Macleod
 Division of Primary Care, Public and Occupational Health and The Medical School Birmingham, B15 2TT, UK; j.a.macleodbham.ac.uk

https://doi.org/10.1136/jech.58.2.157

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    The report by Jousilahti and colleagues adds to growing evidence of a consistent association between serum inflammatory markers—particularly fibrinogen—and social position.1–3 These authors interpret their data as suggesting that the fibrinogen-social position link is not merely a reflection of the social patterning of prevalent disease, smoking, and obesity (all of which are associated with increased serum fibrinogen and lower social position) as a strong trend of increasing fibrinogen with decreasing social status survived statistical adjustment for these covariates. Fibrinogen, they conclude, is therefore a promising candidate for the “missing link” between social position and cardiovascular health.

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