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Tobacco consumption and bladder cancer in non-coffee drinkers
  1. G López-Abentea,
  2. A Escolarb
  1. aCancer Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain, bHospital Universitario “Puerta del Mar”, Servicio de Medicina Preventiva y Salud Pública, Cádiz, Spain
  1. Dr López-Abente, Servicio de Epidemiología del Cáncer, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Sinesio Delgado, 6, 28029 Madrid, Spain (glabente{at}

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Tobacco consumption is the principal known risk factor for urinary bladder cancer. This relation has been analytically characterised on the basis of different aspects of the smoking habit (inhalation pattern, tobacco type, duration).1 2 Other risk factors described for bladder cancer are occupation and coffee consumption,1 3-5 although results for coffee consumption have been contradictory. The important role of cigarette smoking as a confounding factor has been one of the traditional difficulties hindering research into the association between coffee consumption and bladder cancer. In general, studies that have restricted analysis to non-smokers show a weak positive association for coffee consumption, with no effect observed among the smoker stratum. This latter finding is indicative that coffee drinking could have an “attenuator” effect on the risk associated with tobacco use.

In this report, we present the results of a new analysis of the association between cigarette smoking and bladder cancer, in which coffee drinkers were separated from non-coffee drinkers, an aspect that, to our knowledge, has never been published until now.


Data came from a multicentre case-control study, the design and results of which have been published elsewhere.2 5 In short, all new cases of bladder cancer diagnosed in the period, January 1985 to March 1986 (incident cases) and all those diagnosed in the period, 1983–1984 (prevalent cases), were included. Cases were selected from 12 general hospitals spread throughout five …

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  • Funding: the study was financed by the Fondo de Investigación Sanitaria (FIS) grant 84/745.

  • Conflicts of interests: none.