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Determinants of plasma lipoproteins and coagulation factors in men from Caerphilly, South Wales.
  1. J W Yarnell,
  2. A M Fehily,
  3. J Milbank,
  4. A J Kubicki,
  5. R Eastham,
  6. T M Hayes


    Dietary, social, and constitutional determinants of plasma concentrations of some major risk factors for ischaemic heart disease were investigated in a cross sectional study among 711 men from the general population aged 30-69. For high density lipoprotein cholesterol (HDL-C) six variables were significantly associated with plasma concentrations, and these variables explained 12.6% of the variance. For low density lipoprotein cholesterol (LDL-C), total cholesterol (T-C), and triglyceride 8.4%, 7.5%, and 18.5% of the variance was explained by significantly associated variables. Fibrinogen concentrations determined chemically were significantly associated with age, smoking habit, body mass index, alcohol consumption, and intake of cereal fibre (24.2% variance). These data provide some encouragement for the possibility of dietary intervention to influence plasma concentrations of major risk factors for ischaemic heart disease in men.

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