Article Text

Download PDFPDF
Multiple sclerosis in the Orkney and Shetland Islands. III: Histocompatibility determinants.
  1. D C Poskanzer,
  2. P I Terasaki,
  3. L B Prenney,
  4. J L Sheridan,
  5. M S Park


    Histocompatibility testing was performed in 48 multiple sclerosis patients and two carefully matched control groups in Orkney Islands, an area of high multiple sclerosis prevalence. The frequency of HLA-A3, HLA-B7, and DW2 was comparable in patients and controls. However, HLA-B7 was significantly more common in female patients compared with male patients. A B-cell alloantigen (B-cell 4) was also as frequent in patients as among controls. Strong linkage between HLA-B7, DW2 and B-cell 4 occurred in controls, but not patients; the linkage was particularly striking in female controls. These data are not consistent with theories that relate certain of the histocompatibility antigens to the aetiology of multiple sclerosis.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.