User profiles for "author:Christian Stock"

Christian Stock

Senior Principal Statistician, Boehringer Ingelheim
Verified email at boehringer-ingelheim.com
Cited by 7127

Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised …

H Brenner, C Stock, M Hoffmeister - Bmj, 2014 - bmj.com
Objectives To review, summarise, and compare the evidence for effectiveness of screening
sigmoidoscopy and screening colonoscopy in the prevention of colorectal cancer …

[HTML][HTML] Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

KO Alfarouk, CM Stock, S Taylor, M Walsh… - Cancer cell …, 2015 - Springer
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …

Role of ion channels and transporters in cell migration

A Schwab, A Fabian, PJ Hanley… - Physiological …, 2012 - journals.physiology.org
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy

H Brenner, J Chang–Claude, L Jansen, P Knebel… - Gastroenterology, 2014 - Elsevier
Background & Aims Data from randomized controlled trials on the effects of screening
colonoscopies on colorectal cancer (CRC) incidence and mortality are not available …

Multiparametric magnetic resonance imaging (MRI) and MRI–transrectal ultrasound fusion biopsy for index tumor detection: correlation with radical prostatectomy …

JP Radtke, C Schwab, MB Wolf, MT Freitag, CD Alt… - European urology, 2016 - Elsevier
Background Multiparametric magnetic resonance imaging (mpMRI) and MRI fusion targeted
biopsy (FTB) detect significant prostate cancer (sPCa) more accurately than conventional …

Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts

L Schneider, M Cammer, J Lehman… - Cellular physiology and …, 2010 - karger.com
Cell motility and migration play pivotal roles in numerous physiological and
pathophysiological processes including development and tissue repair. Cell migration is …

Protons make tumor cells move like clockwork

C Stock, A Schwab - Pflügers Archiv-European Journal of Physiology, 2009 - Springer
Cancer accounts for 13% of the yearly total mortality worldwide. Most cancer deaths are the
sequel of metastatic diseases rather than of primary tumor growth. Thus, the major challenge …

[HTML][HTML] Why rankings of biomedical image analysis competitions should be interpreted with care

L Maier-Hein, M Eisenmann, A Reinke… - Nature …, 2018 - nature.com
International challenges have become the standard for validation of biomedical image
analysis methods. Given their scientific impact, it is surprising that a critical analysis of …

Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange

C Stock, B Gassner, CR Hauck, H Arnold… - The Journal of …, 2005 - Wiley Online Library
Their glycolytic metabolism imposes an increased acid load upon tumour cells. The surplus
protons are extruded by the Na+/H+ exchanger (NHE) which causes an extracellular …

[HTML][HTML] Proton channels and exchangers in cancer

EP Spugnini, P Sonveaux, C Stock… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Although cancer is characterized by an intratumoral genetic heterogeneity, a totally
deranged pH control is a common feature of most cancer histotypes. Major determinants of …