Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II
SF Zhou - Clinical pharmacokinetics, 2009 - Springer
Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …
[HTML][HTML] Historical perspective of traditional indigenous medical practices: the current renaissance and conservation of herbal resources
SY Pan, G Litscher, SH Gao, SF Zhou, ZL Yu… - Evidence-based …, 2014 - hindawi.com
In recent years, increasing numbers of people have been choosing herbal medicines or
products to improve their health conditions, either alone or in combination with others. Herbs …
products to improve their health conditions, either alone or in combination with others. Herbs …
[HTML][HTML] New perspectives on how to discover drugs from herbal medicines: CAM's outstanding contribution to modern therapeutics
SY Pan, SF Zhou, SH Gao, ZL Yu, SF Zhang… - Evidence-based …, 2013 - hindawi.com
With tens of thousands of plant species on earth, we are endowed with an enormous wealth
of medicinal remedies from Mother Nature. Natural products and their derivatives represent …
of medicinal remedies from Mother Nature. Natural products and their derivatives represent …
Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4
SF Zhou - Current drug metabolism, 2008 - ingentaconnect.com
Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …
Molecular mechanisms for tumour resistance to chemotherapy
ST Pan, ZL Li, ZX He, JX Qiu… - Clinical and Experimental …, 2016 - Wiley Online Library
Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …
Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
Abstract Cytochrome P450 (CYP) 3A4 is the most abundant enzyme of CYPs in the liver and
gut that metabolizes approximately 50% currently available drugs. A number of important …
gut that metabolizes approximately 50% currently available drugs. A number of important …
Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …
Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2
SF Zhou, LP Yang, ZW Zhou, YH Liu, E Chan - The AAPS journal, 2009 - Springer
Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of
clinically important drugs (eg, clozapine, tacrine, tizanidine, and theophylline), a number of …
clinically important drugs (eg, clozapine, tacrine, tizanidine, and theophylline), a number of …
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …