Mitochondrial health is critically dependent on the ability of mitochondria to undergo
changes in mitochondrial morphology, a process which is regulated by mitochondrial …

Hypoxia inducible factor (HIF) is an oxygen-sensitive transcription factor that enables
aerobic organisms to adapt to hypoxia. This is achieved through the transcriptional …

Introduction: New treatments are required to improve clinical outcomes in patients with acute
myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart …

Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of
malignancies, but it causes a dose-related cardiotoxicity that can lead to heart failure in a …

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in
children and its pathogenesis has been associated with the developmental defect of the …

Background—Despite the promise shown by stem cells for restoration of cardiac function
after myocardial infarction, the poor survival of transplanted cells has been a major issue …

Abstract Aims Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tolerance
against acute myocardial ischaemia–reperfusion injury (IRI). However, the mechanism …

Compact CRISPR/Cas9 systems that can be packaged into an adeno-associated virus
(AAV) hold great promise for gene therapy. Unfortunately, currently available small Cas9 …

Background: Molecular targeted chemotherapies have been shown to significantly improve
the outcomes of patients who have cancer, but they often cause cardiovascular side effects …

Background: Electronic cigarettes (e-cigarettes) have experienced a tremendous increase in
use. Unlike cigarette smoking, the effects of e-cigarettes and their constituents on mediating …