Background Chronic kidney disease is characterised by low estimated glomerular filtration
rate (eGFR) and high albuminuria, and is associated with adverse outcomes. Whether these …

OBJECTIVE: To determine which simple index of overweight and obesity is the best
discriminator of cardiovascular risk factors. STUDY DESIGN AND SETTING: This is a meta …

Objective To estimate the relative risk for fatal coronary heart disease associated with
diabetes in men and women. Design Meta-analysis of prospective cohort studies. Data …

Background The benefits of reducing blood pressure on the risks of major cardiovascular
disease are well established, but uncertainty remains about the comparative effects of …

Background Raised blood pressure is an important risk factor for cardiovascular diseases
and chronic kidney disease. We estimated worldwide trends in mean systolic and mean …

Background Overweight and obesity are increasing worldwide. To help assess their
relevance to mortality in different populations we conducted individual-participant data meta …

Background Hypertension can be detected at the primary health-care level and low-cost
treatments can effectively control hypertension. We aimed to measure the prevalence of …

Background Whether rapid lowering of elevated blood pressure would improve the outcome
in patients with intracerebral hemorrhage is not known. Methods We randomly assigned …

Background The effects of pharmacological blood pressure lowering at normal or high-
normal blood pressure ranges in people with or without pre-existing cardiovascular disease …

Examining onsets of political instability in countries worldwide from 1955 to 2003, we
develop a model that distinguishes countries that experienced instability from those that …