Localized ecological systems are known to shift abruptly and irreversibly from one state to
another when they are forced across critical thresholds. Here we review evidence that the …

Methane is an important greenhouse gas, responsible for about 20% of the warming
induced by long-lived greenhouse gases since pre-industrial times. By reacting with …

There is encouraging evidence that structured psychological treatments for depression, in
particular cognitive therapy, can reduce subsequent relapse after the period of initial …

Drosophila melanogaster is a proven model system for many aspects of human biology.
Here we present a two-hybrid–based protein-interaction map of the fly proteome. A total of …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …

Molecular genetic maps are commonly constructed by analyzing the segregation of
restriction fragment length polymorphisms (RFLPs) among the progeny of a sexual cross …

This study evaluated mindfulness-based cognitive therapy (MBCT), a group intervention
designed to train recovered recurrently depressed patients to disengage from dysphoria …

Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …

SWAT is the acronym for Soil and Water Assessment Tool, a river basin, or watershed, scale
model developed by Dr. Jeff Arnold for the USDA Agricultural Research Service (ARS) …

A conceptual, continuous time model called SWAT (Soil and Water Assessment Tool) was
developed to assist water resource managers in assessing the impact of management on …