Occupational sickness among tobacco farmers due to the handling of green tobacco leaves is termed "green symptom." This symptom was investigated among 197 Indian tobacco workers and it was found that 88.83% of the workers were suffering from green symptom when exposed to green tobacco leaves during their occupational operation. Nicotine concentration of the urine was estimated only among male subjects who were smokers. During the exposure period (when subjects were suffering from green symptom), more than a three-fold increase in nicotine concentration in the urine was observed. Both cured and uncured leaves may cause such sickness.