Abstract
Women who had previously given birth to one or more infants with a neural-tube defect (NTD) were recruited into a trial of periconceptional multivitamin supplementation. 1 of 178 infants/fetuses of fully supplemented mothers (0.6%) had an NTD, compared with 13 of 260 infants/fetuses of unsupplemented mothers (5.0%).
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Abortion, Spontaneous / epidemiology
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Ascorbic Acid / administration & dosage
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Avitaminosis / prevention & control
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Clinical Trials as Topic
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Drug Combinations
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Female
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Folic Acid / administration & dosage
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Follow-Up Studies
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Humans
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Infant, Newborn
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Neural Tube Defects / epidemiology
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Neural Tube Defects / prevention & control*
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Niacinamide / administration & dosage
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Pregnancy
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Prospective Studies
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Pyridoxine / administration & dosage
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Riboflavin / administration & dosage
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Thiamine / administration & dosage
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Vitamin A / administration & dosage
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Vitamin D / administration & dosage
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Vitamins / administration & dosage*
Substances
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Drug Combinations
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Vitamins
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Vitamin A
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Vitamin D
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Niacinamide
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Folic Acid
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Pyridoxine
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Ascorbic Acid
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Riboflavin
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Thiamine