Abstract
Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ‘‘global’’ or ‘‘targeted’’ manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies.
In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies.
Keywords: Mass spectrometry, MS, MS-based genomics, MS-based proteomics, MS-based metabolomics, MS-based lipidomics, Meta-omics.
Current Organic Chemistry
Title:The Role of Mass Spectrometry in the “Omics” Era
Volume: 17 Issue: 23
Author(s): Francesco Di Girolamo, Isabella Lante, Maurizio Muraca and Lorenza Putignani
Affiliation:
Keywords: Mass spectrometry, MS, MS-based genomics, MS-based proteomics, MS-based metabolomics, MS-based lipidomics, Meta-omics.
Abstract: Mass spectrometry (MS) is one of the key analytical technology on which the emerging ‘‘-omics’’ approaches are based. It may provide detection and quantization of thousands of proteins and biologically active metabolites from a tissue, body fluid or cell culture working in a ‘‘global’’ or ‘‘targeted’’ manner, down to ultra-trace levels. It can be expected that the high performance of MS technology, coupled to routine data handling, will soon bring fruit in the request for a better understanding of human diseases, leading to new molecular biomarkers, hence affecting drug targets and therapies.
In this review, we focus on the main advances in the MS technologies, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies.
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Cite this article as:
Girolamo Di Francesco, Lante Isabella, Muraca Maurizio and Putignani Lorenza, The Role of Mass Spectrometry in the “Omics” Era, Current Organic Chemistry 2013; 17 (23) . https://dx.doi.org/10.2174/1385272817888131118162725
DOI https://dx.doi.org/10.2174/1385272817888131118162725 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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