Chest
Original ResearchCOPDCOPD and the Risk of Depression
Section snippets
Data Source
We used the UK-based General Practice Research Database (GPRD) to conduct a follow-up study with a nested case-control analysis. The GPRD has been described in detail elsewhere.14 It is a large primary-care database established in 1987 that encompasses some 5 million patients who are enrolled with selected GPs throughout the United Kingdom. The GPs who contribute data to the GPRD have been trained to record medical information in a standard manner and to supply it anonymously. The recorded
Results
We identified 35,772 patients with COPD and the same number of matched patients in the COPD-free comparison group. The study population encompassed slightly more men (51.3%) than women (48.7%). Almost three-quarters (73.3%) of the study population were 60 years or older at the time of the first recorded COPD diagnosis. A previous history of depression was slightly more common among patients with COPD (23.1%) than in the COPD-free comparison group (16.8%).
After excluding patients with prevalent
Discussion
In this large observational study, the prevalence of depression was slightly higher among patients with COPD (23.1%) than in the COPD-free comparison group (16.8%), which is consistent with the range of previously reported estimates in the literature.4 In the follow-up analysis, we found an increased risk of developing an incident diagnosis of depression among patients with COPD as compared with patients without COPD, particularly in women, which is in line with reports from the literature
Acknowledgments
Author contributions: Ms Schneider: contributed to the study concept and design, analysis and/or interpretation of data, drafting of the manuscript, statistical analysis, and administrative, technical, or material support. She had full access to all data in the study and gave final approval of the manuscript.
Dr Jick: contributed to the study concept and design, acquisition of data, analysis and/or interpretation of data, and critical revision of the manuscript for important intellectual
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2022, Journal of Psychosomatic ResearchCitation Excerpt :They found no other differences between COPD and non-COPD groups in attention, memory, or language domains (17). Depression is a common comorbidity in COPD patients, and depression risk is known to increase with greater COPD severity (42). The prevalence of depression in COPD varies considerably among studies, ranging between 10% and 57% (33).
Funding/Support: This study was funded by an unconditional grant from Nycomed GmbH.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).