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The effect of rehabilitation at different stages of development of rats marginally malnourished for ten to twelve generations

Published online by Cambridge University Press:  26 February 2008

R. J. C. Stewart ,
Hilda Sheppard ,
R. Preece  and
J. C. Waterlow
R. J. C. Stewart
Affiliation:
Clinical Nutrition and Metabolism Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WCr E 7HT
Hilda Sheppard
Affiliation:
Clinical Nutrition and Metabolism Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WCr E 7HT
R. Preece
Affiliation:
Clinical Nutrition and Metabolism Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WCr E 7HT
J. C. Waterlow
Affiliation:
Clinical Nutrition and Metabolism Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WCr E 7HT
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Abstract

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1. Rats which have been maintained for ten to twelve generations on diets of low protein value were rehabilitated in utero (group P), from birth (group F) and from 4 weeks of age (group W).

2. Group W showed little change in physique, behaviour or learning, indicating that for recovery to be effective refeeding must begin earlier.

3. Group F just failed to attain full physical recovery (90%) whereas group P overgrew by 18.6% in weight and 8.5%; in length.

4. In a test designed to evaluate learning ability rehabilitated rats of groups P and F were significantly less successful than normal rats, but more successful than rats of group W or rats of the original undernourished colony.

5. Rehabilitation for a further two generations in groups F and P corrected any residual physical and behavioural defects but produced no further improvement on the Lashley (I 938) jumping platform.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 43 , Issue 3 , May 1980 , pp. 403 - 412
Copyright
Copyright © The Nutrition Society 1980

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