Original ResearchFull Report: Clinical—Alimentary TractDietary Fiber Intake Reduces Risk for Colorectal Adenoma: A Meta-analysis
Section snippets
Data Sources and Searches
Two investigators (Q.W.B. and Y.W.S.) independently performed computerized literature searches of the MEDLINE and EMBASE databases to identify relevant studies published through July 2013. The following text and/or medical subject heading terms were used: (1) “food” OR “diet” OR “consumption” OR “dietary” OR “intake” OR “fiber” OR “fibre,” (2) “adenoma” OR “polyp” OR “neoplasm” OR “neoplasia,” (3) “colorectal” OR “colon” OR “rectal” OR “large bowel,” and (4) “risk” OR “incidence” OR
Search Results, Study Characteristics, and Quality Assessment
The search strategy generated 10,578 citations, of which 50 were considered of potential value; the full texts of these publications were retrieved for detailed evaluation (Figure 1). Thirty-three of these 50 articles subsequently were excluded for various reasons, and our review of reference lists led to the inclusion of 3 additional articles. Thus, reports of 20 studies involving 10,948 subjects with CRA were included in the meta-analysis (Supplementary Tables 1 and 2). These studies were
Discussion
The results of this meta-analysis support the hypothesis that dietary fiber intake is associated inversely with the risk of CRA. Analyses of high vs low intake and dose-response models indicated that CRA risk was reduced by 28% and 9% per 10-g/day increase, respectively. No potential for a nonlinear association between dietary fiber intake and CRA risk was detected. Furthermore, we observed significant inverse associations with fruit and cereal fiber intakes, but not with vegetable fiber intake.
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2022, Seminars in Cancer BiologyCitation Excerpt :The consumption of red and processed meat was shown to increase risk for CRC [82,83]. Similarly, a daily intake of calcium and dietary fiber that is lower than 700–1000 mg/day and 10 g/day, respectively, is also associated with a high risk of CRC [84,85]. Although several studies suggest the role of antioxidants in cancer prevention, there is less evidence that suggests that antioxidants are favorable for the prevention of CRC [86].
Conflicts of interest The authors disclose no conflicts.
Funding Supported by the National Natural Science Foundation of China (no. 81072025).