StatisticsHow to deal with regression to the mean in intervention studies
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2022, Seminars in Arthritis and RheumatismCitation Excerpt :Although “true” placebo effect may occur, our results clearly show that RTM exists in RP trials, and simulations suggest that its magnitude may explain a large part of the placebo response in RP trials. If allocation to treatment and placebo arms (or periods in the case of a crossover trial) is properly randomized, RTM should equally affect both groups [12]. Yet, this finding may have an impact on the design of future clinical trials.
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2022, Child Abuse and NeglectCitation Excerpt :Third, in both models we found the child neglect at pre-treatment control variable to be predictive of reduction of child neglect. This finding is not surprising given that as a consequence of regression to the mean the change between baseline and follow-up is related to the initial level, particularly in high-risk samples such as ours (Twisk & Proper, 2004; Yudkin & Stratton, 1996). Nevertheless, the size of the effect in both models indicates that the intervention program was notably beneficial for families starting the program with a high severity of child neglect.
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