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Nutrition and pancreatic cancer

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Epidemiologic evidence on the relation between nutrition and pancreatic cancer is reviewed. A number of epidemiologic studies of diet and cancer of the pancreas have been reported including descriptive, case-control, and cohort studies. Overall, fairly consistent patterns of positive associations with the intake of meat, carbohydrates, and dietary cholesterol have been observed. Consistent inverse relationships with fruit and vegetable intakes and, in particular, with two markers of such foods, namely fiber and vitamin C, also have been noted. However, the methodologic limitations of these studies, particularly the descriptive and case-control studies, are such that causal inferences regarding these empirical associations currently are not warranted. Future follow-up of existing dietary cohorts should enable more precise assessment of the possible role of diet in the etiology of cancer of the pancreas.

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References

  1. American Cancer Society. Cancer Facts and Figures 1995. Atlanta, GA (USA): American Cancer Society, 1995.

    Google Scholar 

  2. Parkin DM, Muir CS, Whelan SL, Gao YT, Ferlay J, Powell J, eds. Cancer Incidence in Five Continents, Vol. VI. Lyon, France: International Agency for Research on Cancer, 1992; IARC Sci. Pub. No. 120.

    Google Scholar 

  3. Howe GR. Pancreatic cancer. In: Trends in Cancer Incidence and Mortality. Oxford, UK: Imperial Cancer Research Fund, 1994; Cancer Surveys, Vol. 19: 139–58.

    Google Scholar 

  4. International Agency for Research on Cancer. Tobacco Smoking. Lyon, France: IARC, 1986; IARC Monogr Eval Carcinog Risks Humans, Vol 38.

    Google Scholar 

  5. International Agency for Research on Cancer. Alcobol Drinking, Lyon, France: IARC, 1988; IARC Monogr Eval Carcinog Risks Humans, Vol 44.

    Google Scholar 

  6. International Agency for Research on Cancer. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal. Lyon, France: IARC, 1991; IARC Monogr Eval Carcinog Risks Humans, Vol 51.

    Google Scholar 

  7. Greenland S, Morgenstern H. Ecological bias, confouding, and effect modification. Int J Cancer 1989; 18: 269–74.

    Google Scholar 

  8. Durbec JP, Chevillotte JM, Bidart P, Berthezene P, Sarles H. Diet, alcohol, tobacco and risk of cancer of the pancreas: A case-control study. Br J Cancer 1983; 47: 463–70.

    Google Scholar 

  9. Gold EB, Gordis L, Diener MD, et al. Diet and other risk factors for cancer of the pancreas. Cancer 1985; 55: 460–7.

    Google Scholar 

  10. Norell SE, Ahlbom A, Erwald R, et al. Diet and pancreatic cancer: a case-control study. Am J Epidemiol 1986; 124: 894–902.

    Google Scholar 

  11. Mack TM, Yo MC, Hanisch R, Henderson BE. Pancreas cancer and smoking, beverage consumption, and past medical history. JNCI 1986; 76: 49–60.

    Google Scholar 

  12. Raymond L, Infante F, Tuyns AJ, Voirol M, Lowenfels AB. Alimentation et cancer du pancréas. Gastroenterol Clin Biol 1987; 11: 488–92.

    Google Scholar 

  13. Falk RT, Pickle LW, Pontham ET, Correa P, Fraumeni JFJr. Life-style risk factors for pancreatic cancer in Louisiana: a case-control study. Am J Epidemiol 1988; 128: 324–36.

    Google Scholar 

  14. Olsen GW, Mandel JS, Gibson RW, Wattenberg LW, Schuman LM. A case-control study of pancreatic cancer and cigarettes, alcohol, coffee and diet. Am J Public Health 1989; 79: 1016–9.

    Google Scholar 

  15. Goto R, Masuoka H, Yoshida K, Mori M, Miyake H. A case-control study of cancer of the pancreas. Japanese J Cancer Clinics 1990; 36: 344–50.

    Google Scholar 

  16. Howe GR, Jain M, Miller AB. Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study. Int J Cancer 1990; 45: 604–8.

    Google Scholar 

  17. La Vecchia C, Negri E, D'Avanzo B, et al. Medical history, diet and pancreatic cancer. Oncology 1990; 47: 463–6.

    Google Scholar 

  18. Negri E, La Vecchia C, Franceschi S, D'Avanzo B, Parazzini F. Vegetable and fruit consumption and cancer risk. Int J Cancer 1991; 48: 350–4.

    Google Scholar 

  19. Bueno de Mesquita, Moerman HB, Runia CJ, Maisonneuve P. Are energy and energy-providing nutrients related to exocrine carcinoma of the pancreas? Int J Cancer 1990; 45: 435–44.

    Google Scholar 

  20. Bueno de Mesquita, Maisonneuve P, Runia S, Moerman CJ. Intake of foods and nutrients and cancer of the exocrine pancreas: a population-based case-control study in the Netherlands. Int J Cancer 1991; 48: 540–9.

    Google Scholar 

  21. Farrow DC, Davis S. Diet and the risk of pancreatic cancer in men. Am J Epidemiol 1990: 132: 423–31.

    Google Scholar 

  22. Baghurst PA, McMichael AJ, Slavotinek AH, Baghurst KI, Boyle P, Walker AM. A case-control study of diet and cancer of the pancreas. Am J Epidemiol 1991: 134: 167–79.

    Google Scholar 

  23. Ghadirian P, Simard A, Baillargeon J, Maisonneuve P, Nutritional factors and pancreatic cancer in the francophone community in Montreal, Canada. Int J Cancer 1991; 47: 1–6.

    Google Scholar 

  24. Zatonski W, Przewozniak K, Howe GR, Maisonneuve P, Walker AM, Boyle P. Nutritional factors and pancreatic cancer: a case-control study from south-west Poland. Int J Cancer 1991; 48: 390–4.

    Google Scholar 

  25. Kalaphothaki V, Tzonou A, Hsieh C-c, et al. Nutrient intake and cancer of the pancreas: a case-control study in Athens, Greece. Cancer Causes Control 1993; 4: 383–9.

    Google Scholar 

  26. Lyon JL, Slattery ML, Mahoney AW, Robison LM. Dietary intake as a risk factor for cancer of the exocrine pancreas. Cancer Epidemiol Biomark Prev 1993; 2: 513–8.

    Google Scholar 

  27. Howe GR, Ghadirian P, Bueno de Mesquita HB, et al. A collaborative case-control study of nutrient intake and pancreatic cancer within the SEARCH programme. Int J Cancer 1992; 51: 365–72.

    Google Scholar 

  28. Mills PK, Beeson WL, Abbey DE, Fraser GE, Phillips RL. Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer 1988; 61: 2578–85.

    Google Scholar 

  29. Hirayama T. Epidemiology of pancreatic cancer in Japan. Jpn J Clin Oncol 1989; 19: 208–15.

    Google Scholar 

  30. Zheng W, McLaughlin JK, Gridley G, et al. A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States). Cancer Causes Control 1993; 4: 477–82.

    Google Scholar 

  31. Shibata A, Mack TM, Paganini-Hill A, Ross RK, Henderson BE. A prospective study of pancreatic cancer in the elderly. Int J Cancer 1994; 58: 46–9.

    Google Scholar 

  32. Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer 1975; 15: 617–31.

    Google Scholar 

  33. Prentice RI, Sheppard L. Dietary fat and cancer: consistency of the epidemiologic data, and disease prevention that may follow from a practial reduction in fat consumption. Cancer Causes Control 1990; 1: 81–97.

    Google Scholar 

  34. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124: 17–27.

    Google Scholar 

  35. Howe GR. Re: ‘Total energy intake: implications for epidemiologic analyses’ (Letter). Am J Epidemiol 1989; 129: 1314–5.

    Google Scholar 

  36. Pike MC, Bernstein, Peters RK. Re: “Total energy intake: implications for epidemiologic analyses” (Letter). Am J Epidemiol 1989; 129: 1312–3.

    Google Scholar 

  37. Howe GR. “Energy Adjustment of Macronutrients: Another View” in Session “Energy Adjustment” at Harvard School of Public Health Conference on Dietary Assessment Methods, Combining Theory and Practice. Boston, MA (USA), January 24, 1995.

  38. Howe GR, Benito E, Castelleto R, et al. Dietary intake of fiber and decreased risk of cancers of the colon and rectum: Evidence from the combined analysis of 13 case-control studies. JNCI 1992; 84: 1887–96.

    Google Scholar 

  39. Chang SS, Peterson RJ, Ho CT. Chemical reactions involved in the deep frying of foods. J Am Oil Chem Soc 1978; 55: 718–27.

    Google Scholar 

  40. Friedenreich CM, Slimani N, Riboli E. Measurement of past diet: review of previous and proposed methods. Epidemiol Rev 1992; 14: 177–96.

    Google Scholar 

  41. National Research Council. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington DC: National Academy Press; Committee on Diet and Health, National Academy of Sciences, 1989.

    Google Scholar 

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Authors and Affiliations

  1. Division of Epidemiology, School of Public Health, Columbia University, New York

    Geoffrey R. Howe & J. David Burch

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  1. Geoffrey R. Howe
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  2. J. David Burch
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Howe, G.R., Burch, J.D. Nutrition and pancreatic cancer. Cancer Causes Control 7, 69–82 (1996). https://doi.org/10.1007/BF00115639

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