Elsevier

Experimental Neurology

Volume 167, Issue 2, February 2001, Pages 456-459
Experimental Neurology

Brief Communication
Association between Alzheimer's Disease and a Functional Polymorphism in the Myeloperoxidase Gene

https://doi.org/10.1006/exnr.2000.7560Get rights and content

Abstract

A polymorphism in the Myeloperoxidase gene (MPO) has previously been demonstrated to be associated with gender-specific risk in an Alzheimer's Disease (AD) autopsy sample. We have investigated this polymorphism in our own samples of 226 Caucasian cases and 166 controls and 59 Hispanic cases and 75 controls. In Caucasians we find a significant association between MPO genotype and AD (P = 0.03), although we do not observe any effects of gender or any interaction with the APOE gene. Specifically, the MPO GG genotype contributes a 1.57-fold increased risk for AD. In Hispanics there was no effect of MPO genotype, or of MPO genotype in interaction with age or gender, on diagnosis of AD.

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1

These authors contributed equally.

2

To whom correspondence and reprint requests should be addressed. E-mail: [email protected].

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