Unadjusted regression coefficients (95% CIs) for crude association between age at first birth and cardiovascular risk factors at age 44/45 years in the NCDS
| <20 years | 20–24 years | 25–29 years | 30–34 years | >34 years | p Gender difference | p Trend | |
|---|---|---|---|---|---|---|---|
| BMI | |||||||
| Men | 1.23 (0.46 to 1.99) | Ref | −0.38 (−0.74 to −0.03) | −0.56 (−0.97 to −0.14) | −0.98 (−1.42 to −0.54) | 0.005 | <0.001 |
| Women | 0.35 (−0.19 to 0.90) | Ref | −1.10 (−1.54 to −0.67) | −1.73 (−2.29 to −1.17) | −2.03 (−2.68 to −1.38) | <0.001 | |
| Waist:hip ratio | |||||||
| Men | 0.01 (0.002 to 0.02) | Ref | −0.01 (−0.01 to −0.003) | −0.01 (−0.02 to −0.005) | 0.02 (−0.03 to −0.01) | 0.895 | <0.001 |
| Women | 0.01 (0.002 to 0.02) | Ref | −0.01 (−0.02 to −0.01) | −0.01 (−0.02 to −0.01) | −0.02 (−0.03 to −0.01) | <0.001 | |
| SBP | |||||||
| Men | 2.68 (−0.10 to 5.46) | Ref | −0.58 (−1.87 to 0.72) | −0.87 (−2.39 to 0.65) | −3.78 (−5.40 to −2.16) | 0.826 | <0.001 |
| Women | 1.42 (−0.24 to 3.07) | Ref | −1.20 (−2.50 to 0.10) | −1.96 (−3.69 to −0.22) | −3.70 (−5.67 to −1.73) | <0.001 | |
| DBP | |||||||
| Men | 2.15 (0.16 to 4.14) | Ref | −0.37 (−1.30 to 0.56) | −0.34 (−1.41 to 0.74) | −2.92 (−4.06 to −1.77) | 0.572 | <0.001 |
| Women | 1.11 (0.02 to 2.20) | Ref | −0.71 (−1.57 to 0.14) | −0.75 (−1.89 to 0.38) | −2.07 (−3.37 to −0.77) | <0.001 | |
| Total cholesterol | |||||||
| Men | 0.02 (−0.20 to 0.24) | Ref | −0.03 (−0.14 to 0.07) | −0.02 (−0.14 to 0.10) | −0.10 (−0.23 to 0.03) | 0.738 | 0.163 |
| Women | 0.10 (−0.01 to 0.21) | Ref | −0.05 (−0.13 to 0.04) | −0.10 (−0.21 to 0.02) | −0.08 (−0.21 to 0.06) | 0.003 | |
| LDL cholesterol | |||||||
| Men | 0.12 (−0.07 to 0.31) | Ref | −0.01 (−0.10 to 0.08) | 0.02 (−0.09 to 0.12) | −0.03 (−0.13 to 0.08) | 0.138 | 0.458 |
| Women | 0.03 (−0.06 to 0.13) | Ref | −0.06 (−0.13 to 0.02) | −0.17 (−0.26 to −0.07) | −0.14 (−0.26 to −0.02) | <0.001 | |
| HDL cholesterol | |||||||
| Men | −0.05 (−0.11 to 0.02) | Ref | 0.03 (−0.004 to 0.06) | 0.03 (−0.01 to 0.06) | 0.03 (−0.01 to 0.06) | <0.001 | 0.042 |
| Women | −0.04 (−0.08 to 0.01) | Ref | 0.06 (0.03 to 0.10) | 0.13 (0.08 to 0.17) | 0.18 (0.13 to 0.23) | <0.001 | |
| Triglycerides* | |||||||
| Men | −0.95 (−11.15 to 10.43) | Ref | −2.22 (−7.23 to 3.07) | −4.26 (−9.88 to 1.71) | −7.93 (−13.55 to −1.94) | 0.065 | 0.005 |
| Women | 10.77 (4.55 to 17.35) | Ref | −7.39 (−11.48 to −3.12) | −10.47 (−15.66 to −4.96) | −16.62 (−22.22 to −10.62) | <0.001 | |
| HbA1c* | |||||||
| Men | −1.62 (−3.65 to 0.45) | Ref | −1.50 (−2.49 to −0.50) | −2.24 (−3.37 to −1.10) | −2.43 (−3.60 to −1.24) | 0.264 | <0.001 |
| Women | 1.21 (0.20 to 2.22) | Ref | −0.63 (−1.40 to 0.15) | −1.10 (−2.11 to −0.08) | −1.67 (−2.84 to −0.49) | <0.001 | |
| CRP* | |||||||
| Men | 19.34 (−1.75 to 44.96) | Ref | −16.41 (−23.85 to −8.25) | −20.57 (−28.65 to −11.58) | −22.71 (−30.89 to −13.57) | 0.831 | <0.001 |
| Women | 13.99 (0.03 to 29.90) | Ref | −20.69 (−28.37 to −12.19) | −19.42 (−29.49 to −7.91) | −29.99 (−39.95 to −18.37) | <0.001 | |
| Fibrinogen* | |||||||
| Men | 0.32 (−3.29 to 4.05) | Ref | −2.68 (−4.37 to −0.96) | −3.61 (−5.53 to −1.64) | −5.14 (−7.11 to −3.12) | 0.172 | <0.001 |
| Women | 2.18 (−0.10 to 4.51) | Ref | −2.47 (−4.17 to −0.74) | −5.04 (−7.22 to −2.80) | −7.85 (−10.30 to −5.34) | <0.001 | |
| vWF* | |||||||
| Men | −1.28 (−7.37 to 5.20) | Ref | 0.16 (−2.85 to 3.26) | −5.41 (−8.67 to −2.04) | −2.20 (−5.71 to 1.45) | 0.365 | 0.031 |
| Women | −1.41 (−4.94 to 2.25) | Ref | −3.03 (−5.75 to −0.22) | −7.19 (−10.62 to −3.63) | −7.16 (−11.12 to −3.03) | <0.001 | |
*Regression results presented as % difference as outcomes were positively skewed and hence log-transformed for analyses.
BMI, body mass index; CRP, C reactive protein; DBP, diastolic blood pressure; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NCDS, National Child Development Study; SBP, systolic blood pressure; vWF, von Willebrand Factor.