Effect modification of ARV by feeding practice, birth weight, and mode of delivery on the weighted national perinatal MTCT rates, South Africa, 2010
| ARV | Other variable | Unweighted frequency | Weighted MTCT risk estimate% | 95% CI |
|---|---|---|---|---|
| Advanced ARV regimens | No breast milk at all | 22 | 2.11 | 1.28 to 2.95 |
| Exclusive BF | 14 | 3.94 | 1.98 to 5.90 | |
| Mixed BF | 7 | 2.07 | 0.55 to 3.60 | |
| Other ARV regimens | No breast milk at all | 16 | 2.57 | 1.31 to 3.84 |
| Exclusive BF | 9 | 3.42 | 1.19 to 5.66 | |
| Mixed BF | 11 | 4.87 | 2.01 to 7.74 | |
| No ARV | No breast milk at all | 5 | 3.45 | 0.53 to 6.37 |
| Exclusive BF | 9 | 11.50 | 4.67 to 18.33 | |
| Mixed BF | 22 | 11.90 | 7.45 to 16.35 | |
| Advanced ARV regimens | Low birth weight | 8 | 2.39 | 0.54 to 3.54 |
| Normal birth weight | 35 | 2.49 | 1.78 to 3.33 | |
| Other ARV regimens | Low birth weight | 10 | 9.28 | 3.81 to 14.80 |
| Normal birth weight | 26 | 2.32 | 1.40 to 3.23 | |
| No ARV | Low birth weight | 8 | 8.37 | 2.68 to 17.04 |
| Normal birth weight | 28 | 9.15 | 5.69 to 12.01 | |
| Advanced ARV regimens | No C-section | 34 | 2.41 | 1.63 to 3.19 |
| C-section | 9 | 2.72 | 1.05 to 4.38 | |
| Other ARV regimens | No C-section | 32 | 3.52 | 2.31 to 4.72 |
| C-section | 4 | 1.77 | 0.01 to 3.53 | |
| No ARV | No C-section | 27 | 7.46 | 5.00 to 9.93 |
| C-section | 9 | 15.18 | 6.36 to 23.99 |
Refer to figure 1 for ARV categories: advance ARV regimens=groups 1a and 1b; other ARV regimens=groups 2a and 2b; no ARV group=group 3a. Note: the missing ARV information group 3b is excluded from this analysis; Feeding=previous 8 days recall.
ARV, antiretroviral; BF, breast feeding; C-section, caesarean section; MTCT, mother-to-child transmission.