Cost-effectiveness sensitivity (A) and subgroup analysis (B)
| Intervention group (n) | Control group (n) | Cost of intervention (£) | ICER (£) | Bootstrapped one-sided 95% CI for ICER (£) | Probability that intervention is cost effective* | |
| (A) Sensitivity analyses | ||||||
| Base case | 395 | 391 | 385 | 12 111 | 58 881 | 89% |
| Mean intervention and control EQ-5D at 6 months as estimate of baseline | 395 | 391 | 385 | 6055 | 37 159 | 96% |
| Control group mean EQ-5D value at 6 months as estimate of baseline | 395 | 391 | 385 | 7109 | 24 853 | 98% |
| Participant payment of £1 per session | 395 | 391 | 385–32=353 | 10 926 | 69 085 | 91% |
| Participant payment of £2 per session | 395 | 391 | 385–64=321 | 9741 | 64 638 | 92% |
| Intervention group (n) | Control group (n) | Incremental cost (bootstrapped 95%CI) | Incremental QALY (bootstrapped 95%CI) | ICER (bootstrapped one-sided 95%CI) | |
| (B) Subgroup analysis | |||||
| Referral reason | |||||
| CHD only | 307 | 309 | £239 (−51 to 547) | 0.0183 (−50.0047 to 0.0416) | £13 060 (117 893) |
| Mental health (MH) and MH plus CHD | 80 | 76 | £596 (−5304 to 1616) | 0.058 (0.017 to 0.100) | £10 276 (50 925) |
| Gender | |||||
| Male | 135 | 130 | £322 (−5180 to 792) | 0.0084 (–0.0250 to 0.0400) | £38 333 (254 973) |
| Female | 265 | 268 | £326 (−589 to 761) | 0.0362 (0.0111 to 0.0623) | £9006 (390 00) |
| Age | |||||
| <44 years | 69 | 71 | £68 (−5462 to 678) | 0.0656 (0.0137 to 0.1148) | £1037 (16 418) |
| 44–60 years | 135 | 136 | £577 (−5176 to 1373) | 0.0179 (−0.0194 to 0.0561) | £32 235 (314 108) |
| >60 years | 196 | 191 | £244 (−5131 to 586) | 0.0187 (−0.0057 to 0.0424) | £13 048 (153 565) |
| Adherence | |||||
| 0 weeks | 30 | £1785 (25 to 4570) | −0.0114 (−0.0680 to 0.0390) | NA | |
| <16 weeks | 123 | £662 (212 to 1157) | −0.0084 (−0.0384 to 0.0218) | NA | |
| 16 weeks | 247 | –£18 (−5310 to 277) | 0.049 (0.0277 to 0.0706) | −£367 (7068) | |
↵* At the £30 000 per QALY threshold.
EQ5D, EuroQol—5 Dimensions; ICER, incremental cost-effectiveness ratio; QUALY, quality adjusted life year.