Adjusted ORs for maternal pre-pregnancy obesity and adolescents' wheeze at age 15 years
| Predictors | Adjusted* OR (95% CI), p Value | ||
| Ever wheeze | Current wheeze | Current wheeze severity† | |
| Maternal pre-pregnancy weight‡ (n=8874) | |||
| First tertile 35–54 kg | Reference | Reference | Reference |
| Second tertile 55–61 kg | 1.08 (0.90 to 1.29), p=0.44 | 1.28 (0.99 to 1.64), p=0.06 | 1.41§ (1.15 to 1.73), p=0.001 |
| Third tertile 62–130 kg | 1.22§ (1.01 to 1.47), p=0.04 | 1.52§ (1.19 to 1.95), p=0.001 | 1.47§ (1.19 to 1.81), p<0.0005 |
| Continuous predictor (% per kg) | 0.6%§ (0.1% to 1.7%), p=0.03 | 1.5%§ (0.5% to 2.5%), p=0.004 | 0.9%§ (0.0% to 1.8%), p=0.04 |
| Maternal pre-pregnancy BMI (n=8838) | |||
| 19–24.9 (normal) | Reference | Reference | Reference |
| <19 (underweight) | 0.80 (0.58 to 1.09), p=0.15 | 0.87 (0.57 to 1.30), p=0.49 | 0.77 (0.54 to 1.08), p=0.13 |
| 25–29.9 (overweight) | 1.18 (0.95 to 1.47), p=0.13 | 1.13 (0.85 to 1.50), p=0.41 | 1.10 (0.86 to 1.40), p=0.44 |
| ≥30 (obese) | 0.99 (0.66 to 1.48), p=0.94 | 1.54§ (0.97 to 2.44), p=0.07 | 1.24 (0.82 to 1.90), p=0.31 |
| Continuous predictor (% per BMI unit) | 2.8%§ (0.5% to 5.1%), p=0.015 | 4.7%§ (1.9% to 7.7%), p=0.001 | 2.7%§ (0.3% to 5.2%), p=0.03 |
↵* Adjusted for social class at birth, marital status at birth, maternal education, maternal asthma, birth weight, parental smoking during gestation, and adolescent BMI at age 15 years.
↵† Severity of current wheeze, using ordinal regression, coding 0=never, 2=1–3 times, 8=4–12 times, 14=more than 12 times.
↵‡ Tertile cut-offs, calculated from the whole-study population.
↵§ 95% CI for OR significant at least at p<0.05.