Weight change over five years (Q1 to Q5) and relative risk (RR) of major CVD and diabetes during 15 years of follow up in 6194 men. (+) Adjusted for age, social class, smoking, physical activity, alcohol intake, antihypertensive treatment, undiagnosed CHD, FEV1, systolic blood pressure, total cholesterol, and initial BMI
| Loss(782) | Stable(3499) | Moderate gain (4%–10%) (1516) | Substantial gain (>10%)(397) | Test for linear trend* | |
|---|---|---|---|---|---|
| *Test for linear trend with weight change fitted as a continuous variable. | |||||
| Major CVD (1454) | |||||
| Number of cases | 214 | 782 | 350 | 108 | |
| Rates/1000 person years | 23.2 | 17.7 | 18.2 | 22.2 | |
| Age adjusted RR | 1.30 (1.12 to 1.51) | 1.00 | 1.06 (0.93 to 1.20) | 1.29 (1.05 to 1.57) | p = 0.76 |
| Adjusted RR (+) | 1.01 (0.86 to 1.18) | 1.00 | 1.08 (0.95 to 1.23) | 1.32 (1.07 to 1.62) | p = 0.005 |
| Diabetes (327) | |||||
| Number of cases | 39 | 172 | 87 | 29 | |
| Rates/1000 person years | 3.9 | 3.6 | 4.2 | 5.6 | |
| Age adjusted RR | 1.07 (0.76 to 1.52) | 1.00 | 1.17 (0.90 to 1.51) | 1.56 (1.05 to 2.31) | p = 0.03 |
| Adjusted RR (+) | 0.62 (0.42 to 0.90) | 1.00 | 1.26 (0.97 to 1.64) | 1.76 (1.16 to 2.67) | p<0.0001 |