Table 4

Efficacy and effectiveness4-150 of meningococcal C vaccine in published studies

Country (year) AuthorType of studyStudy populationDesignFollow up periodEfficacy/ effectiveness %95% CI
NumberAge
USA (1969) Artenstein et al 9 Efficacy68 000Military recruitsRandomised controlled trial2 months874-151 57, 1004-151
USA (1969/1970) Gold et al 10 Efficacy75 000Military recruitsRandomised controlled trial2 months884-151 52, 1004-151
Brazil (1972) Taunay et al 11 Efficacy135 0006–36 monthsRandomised controlled trial17 monthsNS
(24–36 months)(67)4-151 (8, 89)4-151
Italy (1987/1989) Biselli et al 12 Effectiveness300 000Military recruitsIncidence12 months914-151 30, 994-151
Quebec (1992/1993) De Walls et al 13 Effectiveness1.7 million6 months–20 yearsIncidence4 years7953, 91
(6 months–4 years)(72)(5, 91)
Gregg County (1993/1995) Rosenstein et al 14 Effectiveness17 cases2–29 yearsCase-control8527, 97
84 controls
Catalonia (Spain) 1998–99Effectiveness1.27 million18 months–19 yearsIncidence12 months9263, 98
18 months9271, 98
24 months9478, 98

  • ↵4-150 Data in parentheses refer to specific population subgroups.

  • ↵4-151 Recalculated by Rosenstein et al.14